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The transcriptomic profile of the hippocampal microglia in the irradiated juvenile mouse brain

ABSTRACT: The transcriptomic profile of the hippocampal microglia in the irradiated juvenile mouse brain

PROVIDER: PRJNA628980 | ENA |

REPOSITORIES: ENA

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			Action	DRS
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	SRR11634500.fastq.gz	Fastqsanger.gz
	SRR11634501.fastq.gz	Fastqsanger.gz
	SRR11634502.fastq.gz	Fastqsanger.gz
	SRR11634503.fastq.gz	Fastqsanger.gz

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The transcriptomic profile of the hippocampal microglia in the irradiated juvenile mouse brain

Project description:Cranial irradiation (IR), an effective tool to treat malignant brain tumors, triggers a chronic pro-inflammatory microglial response, at least in the adult brain. Using bulk RNA sequencing, we show that the microglial response in the juvenile mouse hippocampus is rapid, but returns toward normal within 1 week. The sensome of irradiated hippocampal microglia reveals an immediate response that declines after one day. Irradiation of the juvenile brain induces a highly ordered temporal progression of the inflammatory and phenotypic microglial genes

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