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Analysis of expression changes between IL-33 Knock out and WT mice in skin chronic inflammation

ABSTRACT: Analysis of expression changes between IL-33 Knock out and WT mice in skin chronic inflammation

PROVIDER: PRJNA629301 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11639083_1.fastq.gz	Fastqsanger.gz
	SRR11639083_2.fastq.gz	Fastqsanger.gz
	SRR11639084_1.fastq.gz	Fastqsanger.gz
	SRR11639084_2.fastq.gz	Fastqsanger.gz
	SRR11639085_1.fastq.gz	Fastqsanger.gz

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Expression data from endothelial cells isolated from IL-33 knock-out and wildtype rats

Project description:Endothelial cells form the innermost layer of vessel walls and their activation is important for the recruitment of white blood cells to inflammatory lesions and for the formation of new blood vessels. Endothelial expression of IL-33 is prominent in human, guinea pig and rat, while is almost absent in the mouse. We have therefore generated IL-33-deficient rats, a more suitable animal model than the commonly laboratory mouse, to address a knowledge gap in the IL-33 research field by providing an in vivo model system that closely reflects the IL-33 expression in human. We performed here gene-level expression profiling of the endothelial cells isolated from IL-33 knock-out rat dermal blood vessesl and looked for the role of endogenous IL-33 in regulating the endothelial cell phenotype.

2023-12-31 | GSE121577 | GEO

Expression data from endothelial cells isolated from IL-33 knock-out and wildtype rats

Project description:Expression data from endothelial cells isolated from IL-33 knock-out and wildtype rats

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Analysis of expression changes between IL-33 Knock out and WT mice in skin chronic inflammation

Project description:To find differential expression gene between IL-33KO and WT mice, we collected skin epithelial RNA sample after all of mice were treated with DNFB for 22 days. (allergen treat) After RNA-seq analysis, we got 203 genes which showed different expression level between IL-33KO and WT mice after allergen treated.

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Next Generation Sequencing Facilitates Quantitative Analysis of control, SETD6 Knock-out, SETD3 knock-out and SETD6+SETD3 knock-out HeLa cells Transcriptomes

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ARRDC4 knock out Mouse Heart Analysis

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IL-33 blockade impacts mediators of persistence and exacerbation in a model of chronic airway inflammation

Project description:Summary: Blocking IL-33 signaling ameliorates inflammation, tissue remodeling and preserves lung function in a model of persistent and exacerbating airway disease. Background: Severe inflammatory airway diseases are associated with inflammation that fails to resolve, leading to structural changes and an overall environment primed for exacerbations. Objective: We sought to identify and inhibit pathways that perpetuate this heightened inflammatory state, as this could lead to therapies that allow for a more quiescent lung, less predisposed to symptoms and exacerbations. Methods: Using prolonged exposure to house dust mite (HDM) in mice, we developed a mouse model of persistent and exacerbating airway disease characterized by a mixed inflammatory phenotype. Results: We show that lung IL-33 drives inflammation and remodeling beyond the type 2 response classically associated with IL-33 signaling. IL-33 blockade with an IL-33 neutralizing antibody normalized established inflammation, and improved remodeling of both the lung epithelium and lung parenchyma. Specifically, IL-33 blockade normalized persisting and exacerbating inflammatory endpoints, including eosinophilic, neutrophilic and ST2+ CD4+ T cell infiltration. Importantly, we identified a key role for IL-33 in driving lung remodeling, as anti-IL-33 also reestablished the presence of ciliated cells over mucus producing cells and lowered myofibroblast numbers, even in the context of continuous allergen exposure, resulting in improved lung function. Conclusion: Overall, this study shows that elevated IL-33 drives a self-perpetuating amplification loop that retains the lung in a state of lasting inflammation and remodeled tissue, primed for exacerbations. Thus, IL-33 blockade may ameliorate symptoms and prevent exacerbations by quelling persistent inflammation and airway remodeling.

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anaerobic knock-out

Project description:Six different knock-out strains' expression data under anaerobic condition Keywords: parallel sample

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aerobic knock-out

Project description:Six different knock-out strains' expression data under aerobic condition Keywords: parallel sample

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Irf6 wildtype and knock out ChIP-seq

Project description:Irf6 wildtype and knock out ChIP-seq

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Irf6 wildtype and knock out ATAC-seq

Project description:Irf6 wildtype and knock out ATAC-seq