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Recombinant RANKL causes modulation of inflammatory signaling pathways in C2C12 myotubes

ABSTRACT: Recombinant RANKL causes modulation of inflammatory signaling pathways in C2C12 myotubes

PROVIDER: PRJNA629356 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11646638.fastq.gz	Fastqsanger.gz
	SRR11646638_1.fastq.gz	Fastqsanger.gz
	SRR11646638_2.fastq.gz	Fastqsanger.gz
	SRR11646639.fastq.gz	Fastqsanger.gz
	SRR11646639_1.fastq.gz	Fastqsanger.gz

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Recombinant RANKL causes modulation of inflammatory signaling pathways in C2C12 myotubes

Project description:Previous reports indicate that RANKL-RANK signaling participates in regulating muscle mass and strength in denervated animals, while RANKL inhibition by OPG-Fc peptide improves the muscle phenotype in dystrophic mdx mice. RANKL has also been shown to activate STAT3 to regulate osteoclastogenesis, although it is not known whether such interaction also plays a role in skeletal muscle. The objective of this aim is to clarify whether RANKL directly affects skeletal muscle.

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