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Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [RNA-seq]

ABSTRACT: Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [RNA-seq]

PROVIDER: PRJNA634369 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11827400.fastq.gz	Fastqsanger.gz
	SRR11827401.fastq.gz	Fastqsanger.gz
	SRR11827402.fastq.gz	Fastqsanger.gz
	SRR11827403.fastq.gz	Fastqsanger.gz
	SRR11827404.fastq.gz	Fastqsanger.gz

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Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [RNA-seq]

Project description:Using mouse models of several recessive and putative dominant-negative patient mutations we were able to dissect the mechanisms that underlie the recessive and dominant-negative capacities of the corresponding AIRE mutants, including a newly identified dominant-negative variant C446G We also identify an auto-regulatory mechanism by which AIRE negatively modulates its own expression.

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Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

Project description:Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

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Project description:Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [ATAC-seq]

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Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE auto-regulation [ChIP-Seq]

Project description:Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE auto-regulation [ChIP-Seq]

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Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

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Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.

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