Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE auto-regulation [ChIP-Seq]

ABSTRACT: Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE auto-regulation [ChIP-Seq]

PROVIDER: PRJNA694945 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13532213_1.fastq.gz	Fastqsanger.gz
	SRR13532213_2.fastq.gz	Fastqsanger.gz
	SRR13532214_1.fastq.gz	Fastqsanger.gz
	SRR13532214_2.fastq.gz	Fastqsanger.gz
	SRR13532215_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

Project description:Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

| PRJNA634367 | ENA

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE auto-regulation [ChIP-Seq]

Project description:Using mouse models of several recessive and putative dominant-negative patient mutations we were able to dissect the mechanisms that underlie the recessive and dominant-negative capacities of the corresponding AIRE mutants, including a newly identified dominant-negative variant C446G We also identify an auto-regulatory mechanism by which AIRE negatively modulates its own expression.

2021-09-01 | GSE165550 | GEO

Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [RNA-seq]

2021-09-01 | GSE151012 | GEO

Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [ATAC-seq]

2021-09-01 | GSE151011 | GEO

Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [RNA-seq]

Project description:Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [RNA-seq]

| PRJNA634369 | ENA

Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [ATAC-seq]

Project description:Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation [ATAC-seq]

| PRJNA634368 | ENA

Mechanistic dissection of dominant AIRE mutations in mouse models reveals evidence for AIRE auto-regulation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-08-30 | GSE151013 | GEO

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.

Project description:The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention of autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engineered mouse models, we establish that some monoallelic mutants, including C311Y and C446G, cause breakdown of central tolerance. By using RNAseq, ATACseq, ChIPseq, and protein analyses, we dissect the underlying mechanisms for their dominancy. Specifically, we show that recessive mutations result in a lack of AIRE protein expression, while the dominant mutations in both PHD domains augment the expression of dysfunctional AIRE with altered capacity to bind chromatin and induce gene expression. Finally, we demonstrate that enhanced AIRE expression is partially due to increased chromatin accessibility of the AIRE proximal enhancer, which serves as a docking site for AIRE binding. Therefore, our data not only elucidate why some AIRE mutations are recessive while others dominant, but also identify an autoregulatory mechanism by which AIRE negatively modulates its own expression.

| S-EPMC8421262 | biostudies-literature

Project title: Endogenous AIRE-immunoprecipitation from primary human neutrophils

Project description:Autoimmune regulator (AIRE) is a transcriptional regulator. We here assess the role for AIRE in primary human neutrophils. We found that the functional role for AIRE in neutrophils is to regulate the extrinsic apoptotic pathway involving the Fas/TNFR death receptors and Cathepsin G and the expression of unique immune mediators.

2024-01-25 | PXD047989 | Pride

Breakdown of immune tolerance in AIRE-deficient rats induces a severe APECED-like auto-immune disease

Project description:Breakdown of immune tolerance in AIRE-deficient rats induces a severe APECED-like auto-immune disease

| PRJEB25437 | ENA