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Expression data from brain parts (amygdala, hippocampus, prefrontal cortex, and cerebral cortex) from mice with or without chronic mild stress (CMS) treatments.

ABSTRACT: Expression data from brain parts (amygdala, hippocampus, prefrontal cortex, and cerebral cortex) from mice with or without chronic mild stress (CMS) treatments.

PROVIDER: PRJNA637312 | ENA |

REPOSITORIES: ENA

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Expression data from brain parts (amygdala, hippocampus, prefrontal cortex, and cerebral cortex) from mice with or without chronic mild stress (CMS) treatments.

Project description:Accumulation of negative stressful life events caused major depressive disorder (MDD) a major public health problem related to disability around the world. For effective therapy and disease managements, a comprehensive genomic analysis to identify objective signatures is required to grasp pathophysiological changes and applicable markers. This data was from a chronic mild stress (CMS) induced MDD mouse model followed by Affmatrix cDNA expression array (GeneChip Mouse Genome 430 2.0 Array) analysis in amygdala, hippocampus, prefrontal cortex, and cerebral cortex.

2020-06-05 | GSE151807 | GEO

Gene expression analysis of prefrontal cortex in mice exposed to chronic mild stress

Project description:Major depressive disorder (MDD) is a common disorder and is responsible for considerable disability in global functioning, anorexia, and severer medical comorbidity. Recently, some reports showed the relationship between MDD and the metabolic disorders such as diabetes. We examined gene expression profiles in the mice prefrontal cortex using genome-wide microarray technology, and determined gene expression profiles with and without chronic mild stress(CMS) for 4 weeks which was often used to make models of depression. To analyze the candidate genes involved in not only depression but dysfunction of physiological homeostasis like diabetes, we campared the gene expression levels between with and without CMS, then we isolated 494 genes showing a more than 2-fold increase or a less than 1/2-fold decrease, in addition, we chose the isolated genes transcriptional products of both samples were confirmed clearly. The prefrontal cortex of C57Bl/6 N sea mice with and without CMS. We mixed tatal RNA from 7 mice prefrontal cortex per each.

2014-02-28 | E-GEOD-49867 | biostudies-arrayexpress

Prefrontal cortex proteomics of CMS-treated rats

Project description:We used a chronic mild stress (CMS) protocol to separate susceptible-depression, susceptible-anxiety and insusceptible rat subgroups. Differential proteomes in the prefrontal cortex were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry.

2020-10-16 | PXD022045 |

Analysis of changes in transcriptomes of the rat medial prefrontal cortex tissues (mPFC) in vehicle group, chronic mild stress (CMS) group, and CMS+Phloretin group

Project description:Purpose: The goals of this study are to investigate the effects of Phloretin (PHL) on the changes of genes in rat mPFC tissues between Vehicle group, CMS group, and CMS+PHL group. Methods: Vehicle group: Rats received vehicle by oral gavage for 2 weeks, and then were left undisturbed for 3 weeks except for necessary procedures, including handling and routine cleaning for 3 weeks. CMS group: Rats received vehicle by oral gavage for 2 weeks, and then were subjected to eight different stressors for 3 weeks in a random order, including foot shock, water deprivation, cold water swimming, food deprivation, restraint, clip tail, light/dark cycle reversal, and cage tilt. CMS+PHL group: Rats were pre-treated with 20 mg/kg. Phloretin for 2 weeks, and then exposed to above eight stressors randomly together with 20 mg/kg Phloretin for 3 weeks. In each group, we collected mPFC tissues from 3 rats and total RNA was extracted. RNA integrity was assessed using the RNA Nano 6000 Assay Kit of the Bioanalyzer 2100 system. The clustering of the index-coded samples was performed on a cBot Cluster Generation System using TruSeq PE Cluster Kit v3-cBot-HS (Illumina) according to the manufacturer’s instructions. After cluster generation, the library preparations were sequenced on an Illumina Novaseq platform and 150 bp paired-end reads were generated. Results: We found that Phloretin treatment changed some gene expression, especially in neuronal plasticity, compared with CMS group.

2023-02-22 | GSE193284 | GEO

Gene expression analysis of prefrontal cortex in mice exposed to chronic mild stress

2014-02-28 | GSE49867 | GEO

Molecular profiling of insular cortex neurons projecting to the central amygdala

Project description:We used the retro-TRAP protocol (Ekstrand et al 2014) to profile insular cortex neurons that project to the central amygdala

2020-12-24 | GSE163743 | GEO

RNA-Seq of Pre-frontal cortex (PFC) and Amygdala from 3-6 month old adult mice

Project description:We sequenced RNA from Pre-frontal cortex (PFC) and Amygdala from 3-6 month old adult mice.

2016-01-27 | GSE74630 | GEO

Analysis of changes in transcriptomes of the rat medial prefrontal cortex tissues (mPFC) in vehicle group, chronic mild stress (CMS) group, and CMS+Phloretin group

Project description:Analysis of changes in transcriptomes of the rat medial prefrontal cortex tissues (mPFC) in vehicle group, chronic mild stress (CMS) group, and CMS+Phloretin group

| PRJNA795666 | ENA

Gene expression in murine amygdala, cortex, hippocampus and hypothalamus of Pianp-deficient mice

Project description:Pianp (also known as Leda-1) is a type I transmembrane protein with preferential expression in the mammalian central nervous system. We used microarrays to analyze the programme of gene expression in murine brain regions amygdala, cortex, hippocampus and hypothalamus of Pianp deficient mice.

2019-09-06 | GSE124791 | GEO

PTSD mouse amygdala proteome

Project description:Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder. Several studies have attempted to characterize molecular alterations associated with PTSD, but most findings were limited to the investigation of specific cellular markers in the periphery or defined brain regions. In the current study, we aimed to unravel affected molecular pathways/mechanisms in the fear circuitry associated with PTSD. We interrogated a foot shock induced-PTSD mouse model by integrating proteomics and metabolomics profiling data. Alterations at the proteome level were analyzed using in vivo 15N metabolic labeling combined with mass spectrometry in prelimbic cortex (PrL), anterior cingulate cortex (ACC), basolateral amygdala (BLA), central nucleus of amygdala (CeA) and CA1 of hippocampus between shocked and non-shocked (control) mice, with and without fluoxetine treatment.

2022-02-28 | PXD002288 | Pride

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