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C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

ABSTRACT: C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

PROVIDER: PRJNA637394 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11928900.fastq.gz	Fastqsanger.gz
	SRR11928901.fastq.gz	Fastqsanger.gz
	SRR11928902.fastq.gz	Fastqsanger.gz
	SRR11928903.fastq.gz	Fastqsanger.gz
	SRR11928904.fastq.gz	Fastqsanger.gz

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Project description:Reed2004 - Methionine Cycle This model is described in the article: A mathematical model of the methionine cycle. Reed MC, Nijhout HF, Sparks R, Ulrich CM. J. Theor. Biol. 2004 Jan; 226(1): 33-43 Abstract: Building on the work of Martinov et al. (2000), a mathematical model is developed for the methionine cycle. A large amount of information is available about the enzymes that catalyse individual reaction steps in the cycle, from methionine to S-adenosylmethionine to S-adenosylhomocysteine to homocysteine, and the removal of mass from the cycle by the conversion of homocysteine to cystathionine. Nevertheless, the behavior of the cycle is very complicated since many substrates alter the activities of the enzymes in the reactions that produce them, and some can also alter the activities of other enzymes in the cycle. The model consists of four differential equations, based on known reaction kinetics, that can be solved to give the time course of the concentrations of the four main substrates in the cycle under various circumstances. We show that the behavior of the model in response to genetic abnormalities and dietary deficiencies is similar to the changes seen in a wide variety of experimental studies. We conduct computational "experiments" that give understanding of the regulatory behavior of the methionine cycle under normal conditions and the behavior in the presence of genetic variation and dietary deficiencies. This model is hosted on BioModels Database and identified by: BIOMD0000000698. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

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C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

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