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Whole-genome RNA-deep sequencing of pancreatic islets of congenic Nidd/DBA mice

ABSTRACT: Whole-genome RNA-deep sequencing of pancreatic islets of congenic Nidd/DBA mice

PROVIDER: PRJNA638383 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11966504_1.fastq.gz	Fastqsanger.gz
	SRR11966504_2.fastq.gz	Fastqsanger.gz
	SRR11966505_1.fastq.gz	Fastqsanger.gz
	SRR11966505_2.fastq.gz	Fastqsanger.gz
	SRR11966506_1.fastq.gz	Fastqsanger.gz

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Whole-genome RNA-deep sequencing of pancreatic islets of congenic Nidd/DBA mice

Project description:Here, we describe the QTL Nidd/DBA, a diabetogenic allele which was contributed by DBA and enhanced hyperglycemia and β-cell loss. In order to re-address the issue of which variants on chromosome 4 are responsible for this trait, Nidd/DBA recombinant congenic lines were generated on an NZO background. Gene expression profiles of pancreatic islets were generated from congenic mice carrying the initial 13.6 Mbp fragment (RCS-I) of the Nidd/DBA locus. Six genes within the critical region were differentially expressed in pancreatic islets of homozygous Nidd/DBAD/D mice compared to homozygous Nidd/DBAN/N controls.

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