Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression signatures in human B lymphoma cell line VAL

ABSTRACT: Gene expression signatures in human B lymphoma cell line VAL

PROVIDER: PRJNA639560 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Gene expression signatures in human B lymphoma cell line VAL

Project description:To investigate the effect of PD-1 expression on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes related to the cell proliferation of human B-cell lymphoma (HBCL) cell line VAL in vitro.

2020-06-16 | GSE152509 | GEO

ACKR3 promotes CXCL12/CXCR4-mediated migration of lymphoma cells

Project description:Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphoma cell migration towards CXCL12. Here, we propose a model of how ACKR3 controls the migration of the diffused large B-cell lymphoma VAL cells in vitro and in vivo in response to CXCL12. VAL cells expressing full-length ACKR3, but not a truncated version missing the C-terminus, can support the migration of VAL cells lacking ACKR3 (VAL-ko) when allowed to migrate together. This migration of VAL-ko cells is pertussis toxin-sensitive suggesting the involvement of a Gi-protein coupled receptor. RNAseq analysis indicate the expression of chemotaxis-mediating LTB4 receptors in VAL cells. We found that LTB4 acts synergistically with CXCL12 in stimulating the migration of VAL cells. Pharmacologic or genetic inhibition of BLT1R markedly reduces chemotaxis towards CXCL12 suggesting that LTB4 enhances in a contact-independent manner the migration of lymphoma cells. The results unveil a novel mechanism of cell-to-cell-induced migration of lymphoma.

2022-10-13 | GSE169144 | GEO

Gene expression signatures for FGFR1 Knockdown in Mantle cell lymphoma cell line (Z-138)

Project description:Gene expression signatures for FGFR1 Knockdown in Mantle cell lymphoma cell line (Z-138)

| PRJNA574838 | ENA

RNA-seq of HEK 293T cells treated with Val-boroPro

Project description:We report the application of RNA-seq for profiling gene transcription upon treatment of dipeptidyl peptidases 8 and 9 inhibitor, Val-boroPro (VbP). We find no significant changes in gene transcription upon treatment of mammalian cells with Val-boroPro.

2020-09-23 | GSE153744 | GEO

Transcriptional Profiling Identifies Prognostic Gene Signatures for Conjunctival Lymphoma

Project description:Transcriptional Profiling Identifies Prognostic Gene Signatures for Conjunctival Lymphoma

| PRJNA904693 | ENA

Targeted RNA-Seq of Human Lymphoma Cell Line

Project description:Targeted RNA-Seq of Human Lymphoma Cell Line

| PRJNA407679 | ENA

Molecular signatures in natural-killer (NK) cell lymphoma

Project description:NK-cell lymphoma shares strikingly similar molecular features with a distinct subset of gamma-delta T-cell lymphoma. Gene expression profiling of NK-cell lymphoma patient samples was performed to investigate whether molecular signatures can be used to identify entities of peripheral T-cell lymphoma (PTCL) with NK-cell-like features.

2010-03-18 | GSE19067 | GEO

Molecular signatures in peripheral T-cell lymphoma (PTCL)

Project description:Molecular signatures to improve diagnosis in PTCL and prognostication in angioimmunoblastic T-cell lymphoma (AITL). Gene expression profiling of PTCL patient samples was performed to investigate whether molecular signatures can be used to identify distinct entities of PTCL.

2010-02-08 | GSE19069 | GEO

Analysis of gene expression signatures for primary vitreo retinal lymphoma

Project description:Analysis of gene expression signatures for primary vitreo retinal lymphoma

| PRJNA525342 | ENA

BATF3siRNA induced gene expression changes in Hodgkin lymphoma cell line L428.

Project description:In this study, we investigated the effect of BATF3 silecing on gene expression in Hodgkin lymphoma cell line L428.

2017-09-11 | GSE89760 | GEO