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Alterations in MAPK Signaling in Alveolar Bronchiolar Carcinomas From B6C3F1/N Mice Exposed to Antimony Trioxide by Inhalation for 2 Years

ABSTRACT: Alterations in MAPK Signaling in Alveolar Bronchiolar Carcinomas From B6C3F1/N Mice Exposed to Antimony Trioxide by Inhalation for 2 Years

PROVIDER: PRJNA639852 | ENA |

REPOSITORIES: ENA

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Alterations in MAPK Signaling in Alveolar Bronchiolar Carcinomas From B6C3F1/N Mice Exposed to Antimony Trioxide by Inhalation for 2 Years

Project description:To identify transcripts differentially expressed between control samples and spontaneous tumors, or control samples and antimony treated lung tumors, we collected RNA from male and female B6C3F1 mice from a 2-year inhalation NTP bioassay exposed to 0 to 30 mg/m3 antimony trioxide. These samples were interrogated with the Affymetrix Mouse Genome 430 2.0 GeneChip Array. A total of 9941 gene transcripts were differentially expressed between control samples and spontaneous tumors, and 12441 gene transcripts were differentially expressed between control samples and treated antimony tumors (false discovery rate (FDR) < 0.05).

2022-12-31 | GSE152629 | GEO

High antimony resistance strain Enterobacter sp. Z1 mediates biomineralization of antimony trioxide

Project description:Enterobacter sp. Z1 showed resistance to antimony and strong ability to produce antimony trioxide (Sb2O3) minerals. Thus, so the purpose of this project is to clarify mechanism of the biomineralization in strain Z1.

2024-03-21 | PXD050880 |

Overall gene expression comparison between antimony resistant and sensitive Leishmania donovani

Project description:The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani. The antimony resistant and sensitive Leishmania donovani were grown in complete M199 medium with 10% FCS and Penicillin streptomycin mixture. At stationary phase (5 day culture) cells were harvested in sterile Phosphate buffered saline and used for RNA isolation.

2016-07-03 | E-GEOD-62468 | biostudies-arrayexpress

Transcriptional analysis of Leishmania infantum antimony resistant strains using full-genome DNA microarrays

Project description:The aim of the experiment is to detect any gene expression modulation in an antimony resistant L.infantum Sb2000.1 strain compared to an antimony sensitive L.infantum WT strain. We want to identify the modulated genes associated with an antimony resistant phenotype. The Sb2000.1 resistant strain used is about 1000 times more resistant to SbIII than the WT sensitive strain. The full-genome DNA microarrays includes one 70-oligonucleotide probe for each gene of L. infantum. Keywords: drug resistance

2009-08-15 | GSE16965 | GEO

Transcriptional analysis of Leishmania infantum antimony resistant strains using full-genome DNA microarrays

2009-08-15 | E-GEOD-16965 | biostudies-arrayexpress

Transcriptomic analysis of lung epithelial cells after LPS inhalation

Project description:Lung ECs express low levels of MHC-I at their surface. These levels are modestly increase 96h after LPS inhalation. At the transcriptional level, AT1, AT2 and Bronchiolar ECs highly increase the expression of MHC-I coding transcripts that reach level as high as mTECs. The amount of transcripts coding for Tap1, Tap2, Psmb8, Psmb9 and Psmb10 stay low compare to mTECs and seems limiting for an efficient surface expression of MHC-I in these three types of lung ECs.

2021-12-10 | GSE176228 | GEO

Cobalt Induced Oxidative Stress Contributes to Alveolar/Bronchiolar Carcinogenesis in B6C3F1/N Mice

Project description:Cobalt Induced Oxidative Stress Contributes to Alveolar/Bronchiolar Carcinogenesis in B6C3F1/N Mice

| PRJNA639854 | ENA

GENE EXPRESSION PROFILING AND MOLECULAR CHARACTERIZATION OF ANTIMONY RESISTANCE IN Leishmania amazonensis

Project description:Background: Drug resistance is a major problem in leishmaniasis chemotherapy. RNA expression profiling using DNA microarrays is a suitable approach to study simultaneous events leading to a drug-resistance phenotype. Genomic analysis has been performed primarily with Old World Leishmania species and here we investigate molecular alterations in antimony resistance in the New World species L. amazonensis. Methods/Principal Findings: We selected populations of L. amazonensis for resistance to antimony by step-wise drug pressure. Gene expression of highly resistant mutants was studied using DNA microarrays. RNA expression profiling of antimony-resistant L. amazonensis revealed the overexpression of genes involved in drug resistance including the ABC transporter MRPA and several genes related to thiol metabolism. The MRPA overexpression was validated by quantitative real-time PCR and further analysis revealed that this increased expression was correlated to gene amplification as part of extrachromosomal linear amplicons in some mutants and as part of supernumerary chromosomes in other mutants. The expression of several other genes encoding hypothetical proteins but also nucleobase and glucose transporter encoding genes were found to be modulated. Conclusions/Significance: Mechanisms classically found in Old World antimony resistant Leishmania were also highlighted in New World antimony-resistant L. amazonensis. These studies were useful to the identification of resistance molecular markers.

2011-06-11 | GSE26159 | GEO

Cobalt Induced Oxidative Stress Contributes to Alveolar/Bronchiolar Carcinogenesis in B6C3F1/N Mice

Project description:To identify differentially expressed transcripts between control samples and spontaneous tumors, or control samples and cobalt treated tumors, we collected RNA from male and female B6C3F1 mice from a 2-year inhalation NTP bioassay exposed to 0 or 5 mg/m3 cobalt metal dust. These samples were interrogated with the Affymetrix Mouse Genome 430 2.0 GeneChip Array. A total of 11557 gene transcripts were differentially expressed between control samples and spontaneous tumors, and 12420 gene transcripts were differentially expressed between control samples and treated cobalt tumors (false discovery rate (FDR) < 0.05).

2021-09-07 | GSE152630 | GEO

Overall gene expression comparison between antimony resistant and sensitive Leishmania donovani

Project description:The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani.

2016-01-01 | GSE62468 | GEO

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