Gene expression data from Collaborative Cross mice treated with TAK-857
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PROVIDER: PRJNA640650 | ENA |
REPOSITORIES: ENA
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Project description:Eight (8) male mice (4 matched pairs) from each of 45 Collaborative Cross lines were treated with a single oral (gavage) dose of either vehicle (methylcellulose) or TAK-875 (600 mg/kg) to facilitate the evaluation of very early liver events in the pathogenesis of IDILI and the identification of genetic risk factors that influence toxicity susceptibility at the hepatocyte level Microarray profiling in the liver identified treatment-induced changes differing by strain and correlating with serum liver chemistries that were enriched in mitochondrial dysfunction, oxidative stress, bile acid homeostasis and immune response pathways suggesting multiple mechanisms contribute to TAK-875 toxicity. Candidate risk factor genes were then identified using individual-transcript and pathway-based mapping of the expression data and further support the contribution of these mechanisms to TAK-875 toxicity.
2022-03-30 | GSE152852 | GEO
Project description:The data was used for eQTL analysis of cecum gene expression in the Collaborative Cross Breeding Population.
2018-07-01 | GSE96924 | GEO
Project description:The goal of this project was to identify strain-dependent expression of miRNAs in lung tissue from Collaborative Cross founder strains that were sensitized and challenged with house dust mite allergen (Der p 1). We analyzed whole lung RNAs from the eight Collaborative Cross founder strains (n=4/strain, all males) using Affymetrix miRNA 2.0 arrays
2015-03-01 | E-GEOD-63954 | biostudies-arrayexpress
Project description:RNA-Seq was performed on all 8 mouse founder strains of the Collaborative Cross to obtain a comprehensive splicing landscape of each strain.
2014-12-04 | E-MTAB-5020 | biostudies-arrayexpress
Project description:The goal of this project was to identify strain-dependent expression of miRNAs in lung tissue from Collaborative Cross founder strains that were sensitized and challenged with house dust mite allergen (Der p 1).
2015-03-01 | GSE63954 | GEO
Project description:The Collaborative Cross (CC) recombinant inbred panel was conceived as an ideal resource for mammalian system genetics. The pre-CC is a proof-of-concept experiment involving CC lines that have undergone at least five generations of inbreeding. Siblings from these lines were each involved in one of four distinct phenotyping arms, then genotyped on a high-density Affymetrix platform. These mice were initially described in the following reference. Genome Research 2011 Aug;21(8):1213-22 (PMID: 21406540). The goal of this specific project was to identify gene expression QTL using lung tissue from pre-CC mice that were sensitized and challenged with house dust mite allergen (namely, Der p 1). We analyzed whole lung RNAs from 138 pre-Collaborative Cross mice using Illumina WG6v2 arrays. Pre-Collaborative Cross (CC) mice are partially inbred strains created by intercrossing eight founder (parental) strains: 129S1/SvImJ, (129S1), A/J (AJ), C57BL/6J (B6), CAST/Ei (CAST), NOD/LtJ (NOD), NZO/H1LtJ (NZO), PWK/Ph (PWK), and WSB/Ei (WSB). Sister-brother mating in 220 families was done for 5-12 generations. One animal was sampled from 138 unique pre-CC strains, each designated by the prefix OR which denotes Oak Ridge National Laboratory as the original source of these mice. The parental strains are not part of this submission. Hybridizations were performed at the National Human Genome Research InstituteM-bM-^@M-^Ys Gene Expression Core Facility.The resulting data were initially processed using Illumina Genome Studio software and then imported into R (v2.9.2) for post-processing. Normalization was conducted using RMA with quantile normalization and log2 transformation.
2013-11-15 | E-GEOD-51768 | biostudies-arrayexpress
Project description:The Collaborative Cross (CC) recombinant inbred panel was conceived as an ideal resource for mammalian system genetics. The pre-CC is a proof-of-concept experiment involving CC lines that have undergone at least five generations of inbreeding. Siblings from these lines were each involved in one of four distinct phenotyping arms, then genotyped on a high-density Affymetrix platform. The genetic profile of these emerging lines reveals high diversity, balanced allele frequencies, and well-distributed recombination – all ideal qualities for a mapping panel. We have mapped white spot, a discrete trait; body weight, a highly polygenic complex trait; and more than 11,000 liver gene expression traits. These analyses provide a glimpse of the potential mapping power and resolution of the CC. The goal of this project was to identify eQTLs for genome-wide gene expression from liver tissue in pre-CC mice. Gene expression profiling from liver tissue from pre-CC males. Pre-Collaborative Cross (CC) mice are partially inbred strains created by intercrossing eight founder (parental) strains: 129S1/SvImJ, (129S1), A/J (AJ), C57BL/6J (B6), CAST/Ei (CAST), NOD/LtJ (NOD), NZO/H1LtJ (NZO), PWK/Ph (PWK), and WSB/Ei (WSB). Sister-brother mating in 220 families was done for 4-11 generations. One animal was sampled from 157 pre-CC strain. Hybridizations were performed at the Gene Expression Core Facility at The Jackson Laboratory. Samples were divided in six batches of about 11 to 24 samples. Two batches were performed per day. Probe-level data was summarized by a custom CDF file based on Ensembl genes (NCBI 37, Ensembl 49; htttp://brainarray.mbni.med.umich.edu). The parental strains are not part of this submission.
2010-12-01 | E-GEOD-22297 | biostudies-arrayexpress
Project description:Whole-genome sequencing of mouse recombinant inbred lines from the Collaborative Cross panel.
| PRJEB14673 | ENA
Project description:Whole genome sequencing and progress towards full inbreeding of the mouse Collaborative Cross population
| PRJEB31495 | ENA
Project description:To accurately identify the unique transcriptional signatures in collaborative cross mice after exposure to West Nile Virus (or mock/no virus) , RNA isolated from spleen tissue and was analyzed using the nanostring immunology panel.
2016-09-01 | GSE86000 | GEO