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Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles (CAPS) [mRNA-seq]

ABSTRACT: Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles (CAPS) [mRNA-seq]

PROVIDER: PRJNA641143 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12070677.fastq.gz	Fastqsanger.gz
	SRR12070678.fastq.gz	Fastqsanger.gz
	SRR12070679.fastq.gz	Fastqsanger.gz
	SRR12070680.fastq.gz	Fastqsanger.gz
	SRR12070681.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles (CAPS) [miRNA-seq]

Project description:Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles (CAPS) [miRNA-seq]

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Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles (CAPS) [miRNA-seq]

Project description:Mice were exposed to filtered air or CAPs for 30 days and then bone marrow-derived EPCs isolated and cultured for 12 days. RNAs isolated from these mice were used for RNA seq analysis.

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Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles (CAPS) [mRNA-seq]

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Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles

Project description:Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles

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Transcriptomic analysis of endothelial progenitor cells (EPCs) isolated from mice exposed to concentrated air pollution particles

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Expression data from human healthy and lupus EPCs/CACs, and healthy CD133+ bone marrow EPCs

Project description:Systemic lupus erythematosus (SLE) is characterized by increased vascular risk due to premature atherosclerosis independent of traditional risk factors. We previously proposed that interferon-α plays a crucial role in premature vascular damage in SLE. IFN-α alters the balance between endothelial cell apoptosis and vascular repair mediated by endothelial progenitor cells (EPCs) and myeloid circulating angiogenic cells (CACs). Here we demonstrate that IFN-α promotes an antiangiogenic signature in SLE and control EPCs/CACs, characterized by transcriptional repression of IL-1α and β, IL-1 receptor 1 and vascular endothelial growth factor A (VEGF-A) and upregulation of IL-1 receptor antagonist (IL-1RN) and the decoy receptor IL1-R2. IL-1β promotes significant improvement in the functional capacity of lupus EPCs/CACs, therefore abrogating the deleterious effects of IFN-α. We used microarrays to analyze the effect of IFNα on peripheral blood EPCs/CACs and on bone marrow EPCs exposed to proangiogenic stimulation. This SuperSeries is composed of the SubSeries listed below.

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Expression data from endothelial progenitor cells (EPCs)

Project description:Endothelial progenitor cells (EPCs) are a group of cells which can differentiate to mature endothelial cells in a certain culture condition, and were first isolated from adult human peripheral blood by Asahara et al. in 1997. EPCs have a critical role in the restoration of injured vessel endothelium and the neovascularization in the area of ischemia injury. Recently, the role of androgens in the proliferation, differentiation and adhesion of EPCs is more and more focused. Dihydrotestosterone (DHT) is a kind of unmetabolizable androgen. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of regulated genes in DHT-treated EPCs.

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Genome-wide analysis of each stage of EPCs differentiation

Project description:Analysis of regulators of endothelial progenitor cells (EPCs) differentiation at gene expression level. Results provide information of gene expression pattern and critical biological processing during EPCs differentiation. Taken together, we define the network of regulators of cord blood-derived EPCs during EPCs differentiation, which can be used to identify genes involved in vascular pathology. Furthermore, we select the critical regulators and then observe these selected regulator's functionality in vitro and in vivo.

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Expression data from human lupus EPCs/CACs

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