Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex

ABSTRACT: Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex

PROVIDER: PRJNA641650 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12082755.fastq.gz	Fastqsanger.gz
	SRR12082756.fastq.gz	Fastqsanger.gz
	SRR12082757.fastq.gz	Fastqsanger.gz
	SRR12082758.fastq.gz	Fastqsanger.gz
	SRR12082759.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 23

Similar Datasets

Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex (scRNAseq)

Project description:Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex (scRNAseq)

| PRJNA641653 | ENA

Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex (scATACseq)

Project description:Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex (scATACseq)

| PRJNA641654 | ENA

Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex (scATACseq)

Project description:The mammalian cerebral cortex has an unparalleled diversity of cell types, which are generated during development through a series of temporally orchestrated events that are under tight evolutionary constraint and are critical for proper cortical assembly and function. However, the molecular logic that governs the establishment and organization of cortical cell types remains elusive, largely due to the large number of cell classes undergoing dynamic cell-state transitions over extended developmental timelines. Here, we have generated a comprehensive single-cell RNA-seq and single-cell ATAC-seq atlas of the developing mouse neocortex, sampled every day throughout embryonic corticogenesis and at early postnatal ages, complemented with a spatial transcriptomics time-course. We computationally reconstruct developmental trajectories across the diversity of cortical cell classes, and infer their spatial organization and the gene regulatory programs that accompany their lineage bifurcation decisions and differentiation trajectories. Finally, we demonstrate how this developmental map pinpoints the origin of lineage-specific developmental abnormalities linked to aberrant corticogenesis in mutant animals. The data provides a global picture of the regulatory mechanisms governing cellular diversification in the neocortex.

2021-05-06 | GSE153163 | GEO

Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex (scRNAseq)

2021-05-06 | GSE153162 | GEO

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex

Project description:A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex

| PRJNA1071528 | ENA

Molecular Logic of Cellular Diversification in the Mouse Cerebral Cortex

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-05-06 | GSE153164 | GEO

Expression data from mouse cerebral cortex

Project description:Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages Cerebral cortex from two mouse strains [C57BL/6J(B6) and C3H/J (C3H)] at post-natal day 1 (p1) and post-natal 11 weeks (11 wk) were harvested for microarray experiments

2013-10-21 | E-GEOD-46443 | biostudies-arrayexpress

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [ATAC-seq]

Project description:A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [ATAC-seq]

| PRJNA1071529 | ENA

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [CUT&RUN]

Project description:A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [CUT&RUN]

| PRJNA1071530 | ENA

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [ChIP-seq]

Project description:A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex [ChIP-seq]

| PRJNA1071531 | ENA