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Aortic smooth muscle cell phenotype modulation during Marfan syndrome aneurysm formation

ABSTRACT: Aortic smooth muscle cell phenotype modulation during Marfan syndrome aneurysm formation

PROVIDER: PRJNA642963 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12113855_1.fastq.gz	Fastqsanger.gz
	SRR12113855_2.fastq.gz	Fastqsanger.gz
	SRR12113856_1.fastq.gz	Fastqsanger.gz
	SRR12113856_2.fastq.gz	Fastqsanger.gz
	SRR12113857_1.fastq.gz	Fastqsanger.gz

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Aortic smooth muscle cell phenotype modulation during Marfan syndrome aneurysm formation

Project description:We report dynamic temporal and spatial smooth muscle cell phenotype modulation using aortic single cell RNA sequencing in a murine model of Marfan syndrome (Fbn1C1041G/+) and littermate controls. Aortic root/ascending aortic tissue samples from both genotypes were studied at 4 and 24 weeks of age. The non-aneurysmal descending thoracic aorta was also studied at 24 weeks. Finally human aortic tissue from a Marfan syndrome patient undergoing aneurysm repair surgery was studied.

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