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Determine differences in gene expression between OPSCC cell lines with different sensitivity to IR

ABSTRACT: Determine differences in gene expression between OPSCC cell lines with different sensitivity to IR

PROVIDER: PRJNA644620 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12168000_1.fastq.gz	Fastqsanger.gz
	SRR12168000_2.fastq.gz	Fastqsanger.gz
	SRR12168001_1.fastq.gz	Fastqsanger.gz
	SRR12168001_2.fastq.gz	Fastqsanger.gz
	SRR12168002_1.fastq.gz	Fastqsanger.gz

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Determine differences in gene expression between OPSCC cell lines with different sensitivity to IR

Project description:mRNA sequencing was performed on 10 oropharyngeal cancer cell lines (5 HPV-positive and 5 HPV-negative cell lines) for this project. Two cell lines (CU-OP-17 and CU-OP-20) were newly derived from HPV-negative and HPV-positive tonsil cancers, respectively (described in " Sensitivity of human papillomavirus-positive and -negative oropharyngeal cancer cell lines to ionizing irradiation" by Holzhauser et al. This study was performed with the goal to identify differences in gene expression between irradiated and non-irradiated cell line samples. Additionally, the aim was to identify possible changes in genes, involved in DNA repair or DNA damage response of the HPV-positive and HPV-negative cell lines. The data published showed an increase of HPV integration sites after irradiation. Additionally, all HPV-positive cell lines in this study showed expression of HPV encoded genes. However, no direct correlation of changes or expression of DNA repair genes was identified.

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