Project description:Male Sprague-Dawley rats [Crl:CD®(SD)IGS BR], weighing ~250 g at study initiation were obtained from Charles River Laboratories, Inc. (Wilmington, MA). Rats were housed singly in ventilated, stainless steel, wire-bottom hanging cages and fed non-certified Rodent Chow (Harlan Labs, Madison, WI) and water ad libitum and acclimated for at least 5 days after arrival. Rats were randomly assigned to various treatment groups (3 rats/group) and were dosed once daily by oral gavage with vehicle (0.2% hydroxypropylmethylcellulose at a dose volume of 10 ml/kg) or with 30, 100, or 200 mg/kg of A-998679. All rats were fasted overnight after their last dose, weighed and sacrificed under isoflurane anesthesia. Liver and small intestine (jejunum) were flash frozen in liquid nitrogen and stored at −80°C until processing for gene expression profiling on the Affymetrix platform.

2012-07-24 | GSE39525 | GEO

5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (Jejunum)

2012-08-04 | GSE39850 | GEO

Rattus norvegicus strain:Sprague-Dawley rats

Project description:Rattus norvegicus strain:Sprague-Dawley rats Genome sequencing

| PRJNA686507 | ENA

Rattus norvegicus strain:Sprague-Dawley rats

Project description:Rattus norvegicus strain:Sprague-Dawley rats Raw sequence reads

| PRJNA687124 | ENA

5 Day Oral Study of A-998679 in Male Sprague Dawley Rats

Project description:This SuperSeries is composed of the following subset Series: GSE39525: 5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (liver) GSE39850: 5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (Jejunum) Refer to individual Series

2012-08-03 | E-GEOD-39875 | biostudies-arrayexpress

Expression data of CD9 positive germ cells from young and aged Sprague Dawley germ cell specific GFP rats

Project description:Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression in the spermatogonial cells at the foundation of spermatogenesis A full genome microarray was used to determine if distinct pathways of genes were altered in expression in CD9-positive germ cells with age Testes from young (4 months) and aged (21 months) Sprague Dawley rats were subjected to dissociation to isolate a singel cell suspension of germ cells. These cells were used to isolate CD9 positive spermatogonial cells. RNA was isolated from these cells for hybridization on agilent miroarrays.

2013-12-05 | E-GEOD-50143 | biostudies-arrayexpress

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