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Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling [bulk RNA-seq]

ABSTRACT: Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling [bulk RNA-seq]

PROVIDER: PRJNA645676 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12202200.fastq.gz	Fastqsanger.gz
	SRR12202201.fastq.gz	Fastqsanger.gz
	SRR12202202.fastq.gz	Fastqsanger.gz
	SRR12202203.fastq.gz	Fastqsanger.gz
	SRR12202204.fastq.gz	Fastqsanger.gz

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Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling

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Project description:We previously identified Dclk1, a tuft cell marker, marks tumor stem cells (TSCs) in mouse intestinal tumors. In this study, we have identified IL17RB as a cell surface marker distinctively expressed by Dclk1+ tuft-like tumor cells in mouse intestinal tumors. Using this tuft cell marker, we compared and analyzed the transcriptome of Lgr5-tuft marker-, Lgr5+tuft marker-, Lgr5-tuft marker+, and Lgr5+tuft marker+ tumor cells. These analyses revealed that tuft-like tumor cells in the intestinal tumors comprise two distinct subsets: highly differentiated tuft-like tumor cells (Lgr5-tuft marker+ cells) and tuft-like tumor cells with TCS potential (Lgr5+tuft marker+ cells).

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