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Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features [Venus]

ABSTRACT: Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features [Venus]

PROVIDER: PRJNA646661 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12240131.fastq.gz	Fastqsanger.gz
	SRR12240132.fastq.gz	Fastqsanger.gz
	SRR12240133.fastq.gz	Fastqsanger.gz
	SRR12240134.fastq.gz	Fastqsanger.gz
	SRR12240135.fastq.gz	Fastqsanger.gz

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Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features

Project description:Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features

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Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features [L-NICD]

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Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features [Venus]

Project description:Hepatocellular carcinoma (HCC) is the predominant primary liver cancer and an increasing cause of cancer-related deaths worldwide, due in part through increased obesity-associated nonalcoholic steatohepatitis (NASH) and associated fibrosis. The Notch signaling pathway is inappropriately “reactivated” in hepatocytes in obesity and plays an active role in the pathogenesis of NASH-associated fibrosis. We aimed to understand the involvement of Notch in the pathogenesis of mouse and human HCC.

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Comparison of Hob6-Venus positive and negative Flk-1+ cells (Venus reporter)

Project description:ES derived Flk-1+ cells were separated by sorting into Hoxb6 positive and negative populations by Venus reporter. Gene expression was compared between these two groups. Duplicate analysis of Hoxb6-Venus positive and negative Flk-1+ cells.

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Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features

Project description:This SuperSeries is composed of the SubSeries listed below.

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HEK NICD AP-MS - Notch signaling is a core patterning module for vascular morphogenesis, which co-determines the sprouting behaviour of endothelial cells (ECs)

Project description:Notch signaling is a core patterning module for vascular morphogenesis, which co-determines the sprouting behaviour of endothelial cells (ECs). Tight quantitative and temporal control of Notch activity is essential for vascular development, yet the details of Notch regulation in ECs are incompletely understood. We found that ubiquitin-specific peptidase 10 (USP10) interacted with the NOTCH1 intracellular domain (NICD1) to slow the ubiquitin-dependent turnover of this short-lived form of the activated NOTCH1 receptor. Accordingly, inactivation of USP10 reduced NICD1 abundance and stability, and diminished Notch-induced target gene expression in ECs. In mice, loss of endothelial Usp10 increased vessel sprouting and partially restored the patterning defects caused by ectopic expression of NICD1. Thus, USP10 functions as an NICD1 deubiquitinase, which fine-tunes endothelial Notch responses during angiogenic sprouting.

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RNAseq analysis of FACs sorted E-cadherin+, Kit+ and K5-venus+ cells from E15 K5-venus mouse submandibular salivary glands

Project description:We used embryonic day 15 submandibular salivary glands from K5-Venus mice, which were produced using the bovine-K5 promoter driving Venus expression, N=3 separate experiments

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Comparison of Hob6-Venus positive and negative Flk-1+ cells (Venus reporter)

Project description:ES derived Flk-1+ cells were separated by sorting into Hoxb6 positive and negative populations by Venus reporter. Gene expression was compared between these two groups.

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Notch

Project description:Notch

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