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Global transcriptional profiling of tyramine and D-glucuronic acid catabolism in Salmonella

ABSTRACT: Global transcriptional profiling of tyramine and D-glucuronic acid catabolism in Salmonella

PROVIDER: PRJNA647759 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12281900_1.fastq.gz	Fastqsanger.gz
	SRR12281900_2.fastq.gz	Fastqsanger.gz
	SRR12281883_1.fastq.gz	Fastqsanger.gz
	SRR12281883_2.fastq.gz	Fastqsanger.gz
	SRR12281884_1.fastq.gz	Fastqsanger.gz

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Global transcriptional profiling of tyramine and D-glucuronic acid catabolism in Salmonella

Project description:Previously we reported that Salmonella can proliferate by deriving energy from two metabolites that naturally occur in the host as gut microbial metabolic byproducts, namely, tyramine (TYR, an aromatic amine) and D-glucuronic acid (DGA, a hexuronic acid). Salmonella Pathogenicity Island 13 (SPI-13) plays a critical role in the ability of Salmonella to derive energy from TYR and DGA, however the catabolism of these two micronutrients in Salmonella are poorly defined. The objective of this study was to identify the specific genetic components and the regulatory circuits for the construction of the TYR and DGA catabolic pathways in Salmonella. To accomplish this, we employed TYR and DGA-induced global transcriptional profiling and gene functional network analysis.

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