Project description:To identify liver transcripts differentially expressed between control samples and animals exposed to DE-71, we collected RNA from male pups at postnatal day 4 (PND4) after the Wistar Han dams were exposed to 0, 0.1, 15, or 50 mg/kg DE-71. These samples were interrogated with the Affymetrix Rat Genome 230 2.0 GeneChip array A total of 0, 15, and 162 gene transcripts were differentially expressed between control samples and 0.1, 15, and 50 mg/kg DE-71, respectively (using a false discovery rate (FDR) threshold of 0.05). These transcripts were mapped to 0, 13, and 161 genes using Ingenuity Pathway Analysis.
Project description:The goal of this study is to compare miRNAs expressed by EGF treated SWAN-71 cells to miRNAs expressed in untreated control SWAN-71 cells to identify micro RNAs which play a role during EGF-mediated SWAN-71 cell invasion
Project description:The goal of this study is to compare miRNAs expressed by HGF treated SWAN-71 cells to miRNAs expressed in untreated control SWAN-71 cells to identify micro RNAs which play a role during HGF-mediated SWAN-71 cell invasion
Project description:The goal of this study is to compare miRNAs expressed by IFN-gamma treated SWAN-71 cells to miRNAs expressed in untreated control SWAN-71 cells to identify micro RNAs which play a role during IFN-gamma-mediated SWAN-71 cells invasion
Project description:TMT labeling of mitochondrial enrichments from right ventricular specimens from 3 control rats, 3 monocrotaline rats, and 4 monocrotaline rats treated with WNK463.
Project description:Adult Sprague Dawley rats were treated i.g. with 50 mg/kg alpha-naphthylisothiocyanate (ANIT) or vehicle (corn oil). Hepatobiliary liver injury occurred at 24 h postdose in ANIT rats with repair at 120h. Livers were extracted from rats at 24h and 120 h post ANIT exposure. This study investigated differences in mRNA expression between the injury and repair phases in the context of ANIT exposure.