Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: The So-Long project: Sociality and the Reversal of the Fecundity/Longevity Trade-off

PROVIDER: PRJNA650536 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR2532160_1.fastq.gz	Fastqsanger.gz
	ERR2532160_2.fastq.gz	Fastqsanger.gz
	ERR2532170_1.fastq.gz	Fastqsanger.gz
	ERR2532170_2.fastq.gz	Fastqsanger.gz
	ERR2532180_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1002

Similar Datasets

How can ant queens live so long? Genes of multiple longevity pathways change expression with age in the ant Temnothorax rugatulus

Project description:Senescence is manifested by an increase in oxidative stress and a decline in biological functions with age. In most organisms, body maintenance is traded-off with reproduction. The negative relationship between longevity and fecundity is also evident on the molecular level, yet the proximate mechanisms remain poorly understood. Apparently by-passing this trade-off, social insect queens are both extremely long-lived (up to 30 years in some ants) and highly fecund compared to workers. Here, we study changes in gene expression with age and fecundity in queens to determine how the trade-off between those two traits is reshaped. We analyse tissue-specific gene expression in young founding queens and old, highly fecund queens of the ant Temnothorax rugatulus. More genes altered their expression with age in the fat body than in the brain. Despite strong differences in ovary development, few fecundity genes were differentially expressed. However, many longevity genes involved in well-known pathways or lifespan-associated biological processes changed their expression with age indicating that multiple longevity mechanisms are activated successively throughout a queens’ life. Young queens invested in immunity (i.e. activation of the Toll signalling pathway) and resistance against environmental and physiological stress associated with the founding phase (i.e. down regulation of the TOR pathway), while established older queens up-regulate anti-aging mechanisms (i.e. up-regulation of catalase, superoxide dismutase, heat shock 70 kDa proteins). Finally, we identified a number of candidate genes and pathways, potentially involved in reshaping the fertility-longevity trade-off in social insects, shedding light on how this is achieved on a proximate level.

2018-03-06 | GSE111415 | GEO

Project description:Remoulding of dietary effects on the fecundity / longevity trade-off in a social insect

| PRJNA746710 | ENA

The effect of larval diet on the fecundity-longevity relationship and age-related gene expression in Drosophila melanogaster

Project description:Our two main aims were 1) to isolate age-related changes in gene expression in females of the solitary insect, Drosophila melanogaster; and 2) to determine whether experimentally changing the shape of the fecundity-longevity relationship (by changing larvae diet) caused changes in age-related gene expression in these females. To address these aims we extracted RNA from three key tissues (fat body, head and ovary) from females at two time points (10% and 60% mortality phases). Each of these females had experienced one of two treatments: medium-quality larval diet (M) treatment (resulting in a positive fecundity-longevity relationship) and high-quality larval diet (H) treatment (resulting in a negative fecundity-longevity relationship).

2023-08-18 | GSE175623 | GEO

Ant LC-MSMS

Project description:Animal longevity widely differs across species, and even individuals from the same species may exhibit different rates of ageing. In different species, the rate at which individuals actually age is related to the level of their social interactions, but this was still not known in ants. In a given colony, ant individuals are close genetic relatives, exhibit very different behaviours and a contrasted lifespan according to the Caste. Such characteristics constitute main advantages to study relationships between sociality and ageing. Therefore, the aim of this study was to characterize differences in the proteome of Lasius niger queens versus that of domestic and foraging workers. Proteomic data were put in relation with the behaviour of individuals from the three Castes. Hence, it was found that sociality correlates with ant longevity, with i) social immunity enabling the queen to mainly invest in soma protection, and ii) marked exposition of workers to the environment and nutrients inducing metabolic pathways that reduce their lifespan.

2020-08-03 | PXD006779 | Pride

Emergence of enhanced metabolic entanglement during experimental evolution of an interkingdom microbial community

Project description:Obligate symbioses have likely evolved through multiple intermediate steps, resulting in a gradual erosion of independence of initially autonomous entities. Here we observed progression towards an increased entanglement for an engineered mutualistic consortium between Escherichia coli and Saccharomyces cerevisiae. Experimental evolution of this interkingdom community led to a rapid enhancement of metabolic cooperation between partners, including the reinforcement of both selfish and social traits, along with the emergence of a novel dependence of yeast on the bacterial partner for ammonium assimilation. Selection on social traits repeatedly occurred indirectly, via pleiotropies and trade-offs within the cellular regulatory networks, and without the requirement for group selection. We propose that such indirect selection on traits may be a common mechanism in evolutionary transitions towards sociality.

2024-08-08 | PXD047443 | Pride

CIDR Longevity Genes Project

Project description:CIDR Longevity Genes Project

| PRJNA186399 | ENA

Homo sapiens

Project description:CIDR Longevity Genes Project

| PRJNA186400 | ENA

Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischaemic injury

Project description:Near-complete reversal of ERBB2-driven cardiomyocyte dedifferentiation is driven by the Hippo pathway, restoring contractility whilst long-lasting conferring cardioprotection.

2023-02-01 | PXD038450 | Pride

CEST-2.2 stimulates lipid metabolism and promotes longevity in mitochondrial mutant animals (ChIP-Seq)

Project description:ChIP-Seq of H3.3 loading on promoters of genes in short-lived and long-lived mitochondrial mutant nematodes identifies genes which could potentially regulate longevity

2021-10-01 | GSE168500 | GEO

Analysis of transcription profile of the activation tagging mutant zfhd2-1D

Project description:zfhd2-1D is an activation tagging mutant was isolated in a screening of seed longevity. The aim of this project is to know the transcriptional changes that allow this kind of phenotype.

2014-02-06 | E-MEXP-3857 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data