Project description:In previous studies, microcurrent electrical nerve stimulation (MENS) has been also used for pain control and muscular growth, but no literatures study the effects and mechanisms of MENS for DM management. Here we analyzed the effect of MENS and MENS mechanisms using phenotype data and omics data of mouse animal model. The results showed MENS regulated diabetes-related pathways to lower blood glucose.
Project description:Diabetes mellitus (DM) is one of the most common chronic diseases around the world, and diabetic peripheral neuropathy (DPN) is one of the most common complications of DM. We used microarrays to identify the differentially expressed miRNAs in dorsal root ganglia (DRG) tissues from streptozotocin (STZ)-induced diabetic rats, taking normal SD rats as controls, and tried to find out the related genes which may be involved in the development of DPN.
Project description:We observe morphological changes of retinal microglia during early stages of diabetic retinopathy in STZ-treated mice. Therefore, in this experiment we assess the impact of STZ-induced diabetic retinopathy on retinal microglia transcriptome during early stages of disease.
Project description:Impaired wound healing is one of the main reasons that leads to diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes mellitus is not fully understood. Long non-coding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complications. To further identify the roles of LncRNAs in diabetic wound healing, four STZ induced diabetic rat skin tissues and four control rat skin tissues were prepared for a LncRNAs microarray expression profiling by using rat LncRNA Array (4 x 44K, Arraystar).
Project description:We report the side-effects of STZ on the spleen, and foud that the AOS10-FMT could rescure the side-effect of STZ in many factors,such as inflammation
Project description:We report the side-effects of STZ on the liver, and found that the AOS10-FMT could rescure the side-effect of STZ in many factors,such as lipid metabolism and oxidative stress
Project description:We report the side-effects of STZ on the testis, and foud that the AOS10-FMT could rescure the side-effect of STZ in many factors,such as spermatogenesis,lipid metabolism and oxidative stress
Project description:Diabetes mellitus (DM) is one of the most common chronic diseases around the world, and diabetic peripheral neuropathy (DPN) is one of the most common complications of DM. We used microarrays to identify the differentially expressed lncRNAs and mRNAs in dorsal root ganglia (DRG) tissues from streptozotocin (STZ)-induced diabetic rats, taking normal SD rats as controls, and tried to find out the related genes which may be involved in the development of DPN.
