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Effects of PSF inhibitors on histone acetylation in prostate cancer cells [ChIP-seq]

ABSTRACT: Effects of PSF inhibitors on histone acetylation in prostate cancer cells [ChIP-seq]

PROVIDER: PRJNA655683 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12401326.fastq.gz	Fastqsanger.gz
	SRR12401327.fastq.gz	Fastqsanger.gz
	SRR12401328.fastq.gz	Fastqsanger.gz
	SRR12401329.fastq.gz	Fastqsanger.gz
	SRR12401330.fastq.gz	Fastqsanger.gz

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Effects of PSF inhibitors on histone acetylation in prostate cancer cells [ChIP-seq]

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Project description:Prostate cancer is the most common cancer in men and Androgen receptor (AR) downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated long non-coding RNA, CTBP1-AS, located in the antisese region of CTBP1 gene. CTBP1-AS activate AR signaling by epigenetically repress AR-associated cofactors such as CTBP1 by interactign with RNA-binding protein PSF and recruiting HDAC complex to the target promoters. In order to investigate the CTBP1-AS and PSF function in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines after siPSF or siCTBP1-AS treatment. We also treated cells with vehicle or androgen to analyzed the effects of CTBP1-AS and PSF on AR function. Observation of androgen dependent gene expression changes after treatmet with siRNAs targeting CTBP1-AS and PSF with microarray.

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