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ABSTRACT: Bacteroides vulgatus free phage DNA

PROVIDER: PRJNA655697 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12424156_1.fastq.gz	Fastqsanger.gz
	SRR12424156_2.fastq.gz	Fastqsanger.gz
	SRR12424157_1.fastq.gz	Fastqsanger.gz
	SRR12424157_2.fastq.gz	Fastqsanger.gz
	SRR12424158_1.fastq.gz	Fastqsanger.gz

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Effect of Bacteroides vulgatus on colitis and depressive-like behavior in a murine model of inflammatory bowel disease: involvement of the gut-brain axis

Project description:IBD is characterized by chronic recurrences of intestinal inflammation and intestinal immune disturbances.Bacteroides vulgatus can alleviate DSS-induced colitis in mice, but the mechanism is unknown. The aim of this study was to examine the changes in gene expression in the intestinal tissue of mice with colitis following treatment with Bacteroides vulgatus by RNA sequencing.

2023-12-06 | GSE246118 | GEO

Genome-wide RNA-seq of Bacteroides thetaiotaomicron VPI-5482 with Bacteroides phage challenge

Project description:Purpose: Examining the transcriptome of Bacteroides thetaiotaomicron VPI-5482 challenged with Bacteroides phage to assess surface molecule expression changes Methods: Bacteroides thetaiotaomicron was grown in BPRM in vitro or Germ-Free mice were monocolonized with Bacteroides thetaiotaomicron and gavaged with ARB25 phage. Fold change was calculated as live phage versus heat-killed phage treated samples with n=3 biological replicates. Once cells reached an optical density corresponding to mid-log phase growth (absorbance between 0.4-0.5), RNA was isolated and rRNA depleted. Samples were multiplexed for sequencing on the Illumina HiSeq platform at the University of Michigan Sequencing Core. Data was analyzed using Arraystar software (DNASTAR, Inc.) using DEseq2 normalization with default parameters. Genes with significant up- or down-regulation were determined by the following criteria: genes with an average fold-change >5-fold and with at least 2/3 biological replicates with a normalized expression level >1% of the overall average, and a p-value < 0.05 (t test with Benjamini-Hochberg correction) Results: Specific capsule expression was increased in wild-type B. thetaiotaomicron during phage infection in vitro and in vivo. Many corresponding in vivo genes were upregulated as well as other surface layer proteins.

2020-05-01 | GSE147071 | GEO

single bacterial species LC-MS/MS

Project description:Analysis of six types of single bacterial species, including Bacteroides vulgatus ATCC 8482,Bacteroides ovatus ATCC 8483, Bacteroides uniformis ATCC 8492, Blautia hydrogenotrophica DSM 10507, Bacteroides thetaiotaomicron ATCC 29148, Escherichia coli DSM 101114

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Project description:Bacteroides vulgatus&IBD

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Project description:Bacteroides vulgatus&Anti-hyperlipidaemia

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Transcriptome of IL-13 treated small intestinal tissue in Nod2-/- mice

Project description:We previously found that mice deficient in the CD susceptibility gene Nod2 develop small intestinal abnormalities including impaired mucus production by goblet cells and susceptibility to injury, which were associated with interferon-gamma producing intraepithelial lymphocytes. These abnormalities were caused by a striking expansion of a common member of the microbiota, Bacteroides vulgatus. Remarkably, infection of Nod2-deficient mice with the helminth Trichuris muris led to a TH2 response that eliminated B. vulgatus colonization and intestinal abnormalities. In addition, treatment with recombinant IL13 (rIL13) or recombinant IL4 reduced B. vulgatus levels and eliminated goblet cell defects, suggesting that type 2 cytokines alone can reverse intestinal abnormalities in the absence of helminth infection. To determine the mechanism by which type 2 cytokines protected Nod2-/- mice from intestinal abnormalities, we performed RNA-seq on small intestinal tissue from WT, Nod2-/- and rIL13 treated Nod2-/- mice. We found that rIL13 treatment induced a wound healing response characterized by M2 macrophage activation genes. Hence, type 2 cytokines can reverse inflammatory imbalances in the composition of the gut microbiota that occurs in a genetically susceptible host.

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Phocaeicola vulgatus CAG:6

Project description:Bacteroides vulgatus CAG:6 overview

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Project description:Bacteroides vulgatus NLAE-zl-G202

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2022-12-17 | GSE190298 | GEO

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