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Effect of TET deletion on the global DNA methylation status of osteoclasts (RNA-Seq)

ABSTRACT: Effect of TET deletion on the global DNA methylation status of osteoclasts (RNA-Seq)

PROVIDER: PRJNA656819 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12440213.fastq.gz	Fastqsanger.gz
	SRR12440214.fastq.gz	Fastqsanger.gz
	SRR12440215.fastq.gz	Fastqsanger.gz
	SRR12440216.fastq.gz	Fastqsanger.gz
	SRR12440217.fastq.gz	Fastqsanger.gz

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Effect of TET deletion on the global DNA methylation status of osteoclasts (RNA-Seq)

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Effect of Dnmt3a deletion on the global DNA methylation status of osteoclasts

Project description:Epigenetic regulation is a fundamental mechanism mediating various cellular processes. However, epigenetic mechanisms in osteoclastogenesis remain to be elucidated. We performed MBD-seq analysis to investigate DNA methylation in osteoclasts derived from wild-type and osteoclast-specific Dnmt3a knockout mice.

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Effect of TET deletion on the global DNA methylation status of osteoclasts

Project description:This SuperSeries is composed of the SubSeries listed below.

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Comprehensive transcriptome analysis of osteoclasts with the SIK3 deletion and pterosin B treatment.

Project description:Maintenance of bone homeostasis and the balance between bone resorption and formation are crucial for maintaining skeletal integrity. Osteoclasts are responsible for bone resorption and play a vital role in this process. The role of salt-inducible kinase 3 (SIK3) in osteoclast differentiation and maturation and its potential as a therapeutic target for osteoporosis remain poorly understood. Here, we generated osteoclast-specific Sik3 conditional knockout (cKO) mice and investigated the effects of SIK3 deletion on bone homeostasis. Our findings revealed increased bone mineral density and an osteopetrosis phenotype in Sik3 cKO mice, indicating the involvement of SIK3 in bone resorption. Furthermore, we examined the effect of pterosin B, an SIK3 inhibitor, on osteoclast differentiation. Pterosin B treatment inhibits osteoclast differentiation in vitro, reduces the number of multinucleated osteoclasts, and suppresses bone resorption. Therefore, in this study, to better understand the molecular mechanism of SIK3 in osteoclast differentiation and maturation, we performed gene expression profiling of bone marrow monocytes from SIK3 deletion and pterosin B treated mice using RNA sequencing (RNA-seq).

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Project description:Effect of Dnmt3a deletion on the global DNA methylation status of osteoclasts

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Project description:Transcriptional profiling of mouse osteoclasts comparing control osteoclasts from Stat5 flox mice with osteoclasts from Stat5 cKO mice. Two-condition experiment, Stat5 flox cells vs. Stat5 cKO cells

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