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ACGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-027411]

ABSTRACT: aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-027411]

PROVIDER: PRJNA657191 | ENA |

REPOSITORIES: ENA

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aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-024427]

Project description:aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-024427]

| PRJNA657193 | ENA

aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-024427]

Project description:Background and aims: P53 limits the self-renewal of stem cells from various tissue. A Loss of p53 in combination with other oncogenic events results in aberrant self-renewal and transformation of progenitor cells. Here, we investigated whether a loss of p53 as a single genetic lesion is sufficient to induce liver tumor formation. Methods: AlfpCre mice were crossed with Trp53 conditional knockout mice to achieve a liver-specific loss of Trp53. Results: The liver-specific loss of Trp53 results in liver tumor formation. A high percentage of the tumors showed a mixed differentiation of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Conclusion: The liver-specific deletion of Trp53 is sufficient to induce liver tumor formation.

2021-01-22 | GSE156253 | GEO

aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-027411]

2021-01-22 | GSE156252 | GEO

aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/-

Project description:aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/-

| PRJNA657237 | ENA

aCGH analysis of liver tumors generated in FAH-/- Trp53-/- mice, a mouse model of metabolic liver injury

Project description:aCGH analysis of liver tumors generated in FAH-/- Trp53-/- mice, a mouse model of metabolic liver injury

| PRJNA657190 | ENA

aCGH analysis of liver tumors generated in FAH-/- Trp53-/- and FAH-/- mice, a mouse model of metabolic liver injury

Project description:aCGH analysis of liver tumors generated in FAH-/- Trp53-/- and FAH-/- mice, a mouse model of metabolic liver injury

| PRJNA659719 | ENA

Agilent 244A aCGH array for breast, lung, melanoma, ovary, and prostate

Project description:373 tumors were profiled for copy-number alterations with the high-resolution Agilent 244A aCGH Array.

2010-07-29 | GSE20393 | GEO

Agilent 244A aCGH array for squamous cell carcinoma of the lung

Project description:24 SCC tumors were profiled for copy-number alterations with the high-resolution Agilent 244A aCGH Array

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Agilent 244K aCGH data for 10 human gastric cancers

Project description:Copy number alteration (CNA) is a good signpost to identify cancer related genes. CNAs were analyzed using the Agilent 244K array comparative genomic hybridization (aCGH) in fresh-frozen tumor and matched normal tissues from 10 gastric cancer patients.

2015-05-29 | GSE69318 | GEO

Agilent 400K aCGH data for 30 human gastric cancers

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