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In situ Hi-C profiles of DP thymocyltes from control and Suv39h1/Suv39h2 double knockout mice

ABSTRACT: in situ Hi-C profiles of DP thymocyltes from control and Suv39h1/Suv39h2 double knockout mice

PROVIDER: PRJNA657285 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12455366_1.fastq.gz	Fastqsanger.gz
	SRR12455366_2.fastq.gz	Fastqsanger.gz
	SRR12455367_1.fastq.gz	Fastqsanger.gz
	SRR12455367_2.fastq.gz	Fastqsanger.gz
	SRR12455368_1.fastq.gz	Fastqsanger.gz

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in situ Hi-C profiles of DP thymocyltes from control and Suv39h1/Suv39h2 double knockout mice

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Project description:H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes for healthy cellular function. Within all eukaryotic nuclei, heterochromatin and euchromatin are spatially segregated, with euchromatin typically located in the nuclear interior and heterochromatin at the nuclear periphery. Here we investigate the changes in DNA accessibilty in the absence of H3K9me3-dependent heterochromatin by performing ATAC-seq in primary immune cells deficient in both Suv39h1 and Suv39h2 (Suv39DKO), the major mammalian histone methyltransferase enzymes which catalyse heterochromatic H3K9me3 deposition.

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LaminB1 ChIP-seq of DP thymocytes from wildtype and Suv39h1 and Suv39h2 double knockout mice

Project description:H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes for healthy cellular function. Within all eukaryotic nuclei, heterochromatin and euchromatin are spatially segregated, with euchromatin typically located in the nuclear interior and heterochromatin at the nuclear periphery. Here we investigate the disruption of lamina-association in the absence of H3K9me3-dependent heterochromatin by performing LaminB1 ChIP-seq in primary immune cells deficient in both Suv39h1 and Suv39h2 (Suv39DKO), the major mammalian histone methyltransferase enzymes which catalyse heterochromatic H3K9me3 deposition.

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