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RNA-seq profiles of DP thymocytes from control and Suv39h1/Suv39h2 double knockout mice

ABSTRACT: RNA-seq profiles of DP thymocytes from control and Suv39h1/Suv39h2 double knockout mice

PROVIDER: PRJNA657287 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12455382_1.fastq.gz	Fastqsanger.gz
	SRR12455382_2.fastq.gz	Fastqsanger.gz
	SRR12455383_1.fastq.gz	Fastqsanger.gz
	SRR12455383_2.fastq.gz	Fastqsanger.gz
	SRR12455384_1.fastq.gz	Fastqsanger.gz

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ATAC-seq of DP thymocytes from Suv39h1 and Suv39h2 double knockout chimeric mice

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Project description:H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes for healthy cellular function. Here we investigate the disruption of genome organization in the absence of H3K9me3-dependent heterochromatin by performing in situ Hi-C in primary immune cells deficient in both Suv39h1 and Suv39h2 (Suv39DKO), the major mammalian histone methyltransferase enzymes which catalyse heterochromatic H3K9me3 deposition.

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