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Transcriptomic profiling of human senescent cells in the setting of curcumin intervention

ABSTRACT: Transcriptomic profiling of human senescent cells in the setting of curcumin intervention

PROVIDER: PRJNA658072 | ENA |

REPOSITORIES: ENA

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Transcriptomic profiling of human senescent cells in the setting of curcumin intervention

Project description:Aging and age-relataed pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecules would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of curcumin, a polyphenol constituent (up to ∼5%) of the traditional medicine known as turmeric, in targeting senescent cells via induction of programmed cell death. This study demonstrates the impact of curcumin as a medicinal compound on the expression profile of senescent cells and provides a strong rationale for its future application in geriatric medicine.

2022-12-31 | GSE156472 | GEO

Transcriptomic profiling of human senescent cells in the setting of grape seed extract intervention

Project description:Transcriptomic profiling of human senescent cells in the setting of grape seed extract intervention

| PRJNA657362 | ENA

Transcriptomic profiling of human senescent cells in the setting of alpha-lipoic acid intervention

Project description:Transcriptomic profiling of human senescent cells in the setting of alpha-lipoic acid intervention

| PRJNA657009 | ENA

Transcriptomic profiling of human senescent cells in the setting of pharmacological intervention (NAD+ and NMN)

Project description:Transcriptomic profiling of human senescent cells in the setting of pharmacological intervention (NAD+ and NMN)

| PRJNA656524 | ENA

Transcriptomic profiling of human senescent cells in the setting of alpha-lipoic acid intervention

Project description:Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecule inhibitors would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of alpha lipoic acid (ALA), a naturally existing antioxidant, in targeting senescent cells via induction of programmed cell death. This study demonstrates the impact of alpha-lipoic acid as a medicinal compound on the expression profile of senescent cells and provides a strong rationale for its future use in geriatric medicine.

2022-12-31 | GSE156184 | GEO

Transcriptomic profiling of human senescent cells in the setting of grape seed extract intervention

Project description:Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecule inhibitors would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of grape seed extract (GSE), a naturally existing source of phytochemicals including terpenoids, carotenoids, and flavonoids, in targeting senescent cells via induction of programmed cell death. This study demonstrates the impact of GSE as a medicinal compound on the expression profile of senescent cells and provides a strong rationale for its future use in geriatric medicine.

2021-10-04 | GSE156301 | GEO

Transcriptomic profiling of human senescent cells in the setting of pharmacological intervention (NAD+ and NMN)

Project description:Aging and age-relataed pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecules would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of two metabolic molecules, NAD+ and NMN, to control the development of the pro-inflammatory phenotype of senescent human stromal cells. This study discloses the impact of NAD+ and NMN on the expression profile of senescent cells and provides a framework for future anti-aging administration with clear rationale.

2022-12-31 | GSE156038 | GEO

Transcriptomic profiling of senescent human stromal cells upon medicinal intervention with rutin

Project description:Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using natural or synthetic agents would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of rutin, a bioactive phytochemical component derived from natural plants specifically ginkgo boliva, in targeting senescent cells via suppression of the SASP. This study demonstrates the efficacy of rutin as medicinal agent in controlling the influence of senescent human stromal cells and provides a strong rationale for its future use in aging intervention and geriatric medicine.

2023-11-02 | GSE190279 | GEO

Transcriptomic profiling of senescent human stromal cells upon medicinal intervention with rutin

Project description:Transcriptomic profiling of senescent human stromal cells upon medicinal intervention with rutin

| PRJNA786575 | ENA

Transcriptomic definition of curcumin treated microglia

Project description:Curcumin is a potent modulator of the inflammatory transcriptome in microglia We have performed global gene expression analysis of BV-2 microglial cells under the following conditions: untreated, 20 µM Curcumin-treated, 100ng/ml LPS-treated, or 20 µM Curcumin-treated + 100ng/ml LPS-treated

2010-09-29 | E-GEOD-23639 | biostudies-arrayexpress

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