Project description:The gene expression program underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of gene expression and chromatin accessibility in fetal tissues. For gene expression, we applied three-level combinatorial indexing to >110 samples representing 15 organs, profiling ~4 million single cells. We leveraged the literature and other atlases to identify and annotate hundreds of cell types and subtypes, both within and across tissues. Our analyses focus on organ-specific specializations of broadly distributed cell types (e.g. blood, endothelial, epithelial), sites of fetal erythropoiesis (which surprisingly included the adrenal gland) and integration with mouse developmental atlases (e.g. conserved specification of blood cells). These data comprise a rich resource for the exploration of in vivo human gene expression in diverse tissues and cell types.

2020-11-01 | GSE156793 | GEO

A human cell atlas of fetal gene expression.

Project description:The gene expression program underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of gene expression and chromatin accessibility in fetal tissues. For gene expression, we applied three-level combinatorial indexing to >110 samples representing 15 organs, ultimately profiling ~4 million single cells. We leveraged the literature and other atlases to identify and annotate hundreds of cell types and subtypes, both within and across tissues. Our analyses focused on organ-specific specializations of broadly distributed cell types (such as blood, endothelial, and epithelial), sites of fetal erythropoiesis (which notably included the adrenal gland), and integration with mouse developmental atlases (such as conserved specification of blood cells). These data represent a rich resource for the exploration of in vivo human gene expression in diverse tissues and cell types.

| S-EPMC7780123 | biostudies-literature

The Fetal and Infant Human Testis Cell Atlas via Single-cell RNA-seq

Project description:The Fetal and Infant Human Testis Cell Atlas via Single-cell RNA-seq

| PRJNA678957 | ENA

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity [scRNAseq-fetal tissue]

Project description:Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity [scRNAseq-fetal tissue]

| PRJNA1102355 | ENA

A high-resolution single-cell multiomic atlas of the human fetal lung - Visium

Project description:A high-resolution single-cell multiomic atlas of the human fetal lung - Visium

| PRJEB54910 | ENA

A high-resolution single-cell multiomic atlas of the human fetal lung - Organoid

Project description:A high-resolution single-cell multiomic atlas of the human fetal lung - Organoid