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Gene expression data from spleen, cervical spinal cord, and thalamic regions of ME7-inoculated mouse

ABSTRACT: Gene expression data from spleen, cervical spinal cord, and thalamic regions of ME7-inoculated mouse

PROVIDER: PRJNA660970 | ENA |

REPOSITORIES: ENA

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Gene expression data from spleen, cervical spinal cord, and thalamic regions of ME7-inoculated mouse

Project description:An essential and remarkable process of the biochemical and physiological features in prion diseases is the conversion of a host-encoded prion protein (PrPC) into a misfolded isoform (PrPSc). The conversion of PrPC and the replication of prions, in cases of peripheral infection, occur following the uptake and subsequent spread of prions to brain via spinal cord. We investigated the changes of gene expression profiles in the spleen, cervical spinal cord and thalamus following intraperitoneal inoculation of ME7 scrapie prion and the inter-tissue alterations of the differentially expressed genes through Venn diagram to find genes which are commonly influenced by ME7 scrapie prion spread in the three tissues.

2021-12-31 | GSE157334 | GEO

Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture

Project description:It has been shown that acupuncture at acupoints GB34 and LR3 inhibits the degeneration of nigrostriatal neurons in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinsonâ??s disease. This preventative effect of peripheral acupuncture stimulation is hypothesized to be transmitted through the spinal cord to the nigrostriatal neurons. The gene expression profile changes following acupuncture at the acupoints were investigated in the cervical spinal cord of an MPTP-induced parkinsonism model using an Affymetrix genechip mouse gene 1.0 ST array. C57BL/6 mice were divided into four experimental groups; â? C: Control, â?¡ M: MPTP-treatment only, â?¢ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, â?£ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from the cervical spinal cord regions of each experimental group (4 experimental group Ã? 2 samples of each experimental group = total 8 samples).

2010-10-23 | E-GEOD-24830 | biostudies-arrayexpress

Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture

2010-10-23 | GSE24830 | GEO

Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture stimulations at GB34 and LR3 inhibit the reduction of tyrosine hydroxylase in the nigrostriatal dopaminergic neurons in the parkinsonism animal models. Especially, behavioral tests showed that acupuncture stimulations improved the motor dysfunction in a previous study. The thalamus is a crucial area for the motor circuit and has been identified as one of the most markedly damaged areas in Parkinson’s disease (PD), so acupuncture stimulations might also have an effect on the thalamic damage. We investigated gene expression profile changes in the thalamic region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; ① C: Control, ② M: MPTP-treatment only, ③ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, ④ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' thalamic regions of each experimental group (4 experimental group × 2 samples of each experimental group = total 8 samples).

2012-01-18 | E-GEOD-35138 | biostudies-arrayexpress

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Single-cell RNA-seq was performed in SHH-treated thalamic organoids

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Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Single-cell RNA-seq was performed in SHH-treated thalamic organoids

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Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

2012-01-18 | GSE35138 | GEO

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

| PRJNA867308 | ENA

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

| PRJNA939719 | ENA

Expression data from periplaque regions in multiple sclerosis spinal cord

Project description:There have been few studies that have focused on the periplaque regions surrounding demyelinated plaques, especially in spinal cords. Areas of incomplete demyelination have been demonstrated but poorly studied. The present study aimed to analyze the molecular immunopathology of periplaque demyelinated lesions (PDLs) in the spinal cord of patients with secondary progressive multiple sclerosis (MS). To achieve this goal, the transcriptomic profiles of PDLs were analyzed in post-mortem tissues derived from the cervical spinal cord of 8 patients with primary or secondary progressive MS.

2014-05-30 | GSE52139 | GEO

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