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Circular RNA expression in tongue squamous cell carcinoma patients

ABSTRACT: Circular RNA expression in tongue squamous cell carcinoma patients

PROVIDER: PRJNA663334 | ENA |

REPOSITORIES: ENA

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Circular RNA expression in tongue squamous cell carcinoma patients

Project description:circRNA microarrays were performed with 2 pairs of tongue squamous cell carcinoma and their matched adjacent tissues. The statistical significance of the difference was estimated by t-test. circRNAs having fold changes 1.5 and p-values 0.05 are selected as the significantly differentially expressed. The data from microarray indicated that there were 54 upregulated and 70 downregulated circRNAs in TSCC tissues.

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RNA expression in tongue squamous cell carcinoma, tumour free tongue tissue and control tongue

Project description:Tongue squamous cell carcinoma is a tumour type with rather low five year survival, around 60%. The poor survival rate has been ascribed to late detection, a high frequency of locoregional recurrence, the occurrence of secondary primary tumours and death due to comorbidity. One reason for development of recurrence is thought to be the existence of transformed cells in areas adjacent to the primary tumour, cancerization field effect. The aim of this study was to map the changes in the tumour free tongue tissue adjacent to tongue tumours compared with healthy control tongue tissue to better understand the cancerization field effect. Tissue biopsies were collected from tumour (T) and tumour free tissue adjacent to the tumour (TF) from patients with tongue squamous cell carcinoma. Control tissue was collected from latter border of the tongue of tumour free healthy volunteers (C). All samples were homogenized and RNA was extracted. The RNA was biotin labelled and run on Illumina HT-12 bead chip array.

2016-12-21 | E-MTAB-4678 | biostudies-arrayexpress

Analysis of differentially expressed long noncoding RNAs, circular RNAs and the associated TF‐mRNA network in tongue squamous cell carcinoma

Project description:Purpose: The purpose of this study was to identify aberrantly expressed lncRNAs, circular RNAs and the associated TF‐mRNA network in TSCC. Methods: Tongue tumor noncoding and mRNA profiles of tongue squamous cell carcinoma and adjacent noncancerous tissues were generated by deep sequencing, using Illumina HiSeq 4000. Results: Using an optimized data analysis workflow. Conclusions: we found a profile of dysregulated lncRNAs, TFs and mRNAs that could serve as prospective clinical biomarkers because of their tissue specificity and association with the tumorigenesis and progression of TSCC.

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Gene expression profiles of oral tongue squamous cell carcinoma tissues.

Project description:Gene expression profiles of oral tongue squamous cell carcinoma tissues. Keywords: human tongue cancer, brachytherapy, biopsy sample, primary tissues

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Project description:Tongue squamous cell carcinoma (TSCC)

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Transcriptomic Dissection of Tongue Squamous Cell Carcinoma

Project description:The head and neck / oral squamous cell carcinoma (HNOSCC) is a diverse group of cancers, which develop from many different anatomic sites and are associated with different risk factors and genetic characteristics. The oral tongue squamous cell carcinoma (OTSCC) is one of the most common types of HNOSCC. It is significantly more aggressive than other forms of HNOSCC, in terms of local invasion and spread. In this study, we aim to identify specific transcriptomic signatures that associated with OTSCC. Keywords: Disease/Control analysis

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RNA expression in squamous cell carcinoma of the tongue and normal tissue adjacent to squamous cell carcinoma of the tongue

Project description:Increasing incidence of squamous cell carcinoma of the tongue (SCCT) in young patients has been reported. In this study, we aimed to investigate the transcriptional profiles in tumour and matched tumour-free tissue from patients with SCCT. Particularly, transcriptional profiles of young patients (< 40 years) were compared with those of old patients (> 50 years), in order to know whether young patients are transcriptionally different to old patients. A total of 12 patients with SCCT treated at The University hospital of Umeå (NUS) were recruited. Three patients were younger than 40 years old at diagnosis (young patient), and the other 9 patients were older than 50 years old (old patient). Biopsies of tumour and tumour-free tissues were fresh-frozen in liquid nitrogen and stored at -80°C until nuclear acid extraction.

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Altered expression of microRNAs in Tongue squamous cell carcinoma (TSCC) and matched nonmalignant tissues (NC)

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Expression analysis of LncRNA in Tongue Squamous Cell Carcinoma (TSCC) and matched nonmalignant tissues (NC)

Project description:Investigation of LncRNA expression level changes in 9 paired of Tongue Squamous Cell Carcinoma specimens

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