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Short term effects of a Methionine Restricted Diet

ABSTRACT: Short term effects of a Methionine Restricted Diet

PROVIDER: PRJNA663881 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12653654_1.fastq.gz	Fastqsanger.gz
	SRR12653654_2.fastq.gz	Fastqsanger.gz
	SRR12653655_1.fastq.gz	Fastqsanger.gz
	SRR12653655_2.fastq.gz	Fastqsanger.gz
	SRR12653656_1.fastq.gz	Fastqsanger.gz

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Short term effects of a Methionine Restricted Diet

Project description:Thirty-two, seven-week old male C57BL/6J mice were obtained from Jackson Labs. Mice were adapted to a 12h/12h reverse light cycle and put on Control diet at 8 weeks of age for 10 days. Food was removed during lights on and restored at lights off. On the day of the experiment, mice were fed Control or MR diet for either 3 or 6 hours. There were 8 mice in each group. Animals were sacrificed using CO2 inhalation and decapitation. The hepatic transcriptome was analyzed for the initial effect of low dietary methionine.

2021-02-22 | GSE158068 | GEO

Transcriptional reprogramming of methionine restricted cells

Project description:The genome-wide transcriptional response of S. cerevisiae cells upon transfer to methionine-restricted media is investigated. DHO strain (BY4742 background) was cultivated batch-wise in SDC media at 30C and 180 rpm up to mid-exponential phase (OD600 ~ 0.6). The cells of the main culture were divided in three aliquots at the mid-exponential phase, centrifuged at 6000 rpm for 5 min, washed twice with deionized and distilled sterile water prior to their transfer to the treatment media. Treatment media comprised of SDC + 0.75% methionine for the methionine-restricted case while SDC is used for the control case. Sample collection for transcriptional profiling was done at the 2nd hour of the transfer. The experiments were carried out in biological triplicates.

2024-01-01 | E-MTAB-12860 | biostudies-arrayexpress

Gene expression in mouse liver in response to short-term calorie restriction

2013-09-26 | GSE50789 | GEO

Gene expression in mouse heart in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in heart in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

2017-05-31 | GSE75572 | GEO

Gene expression in mouse cerebral cortex in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in cerebral cortex in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

2017-05-31 | GSE75569 | GEO

Gene expression in mouse gastrocnemius muscle in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in gastrocnemius muscle (GASTROC) in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

2017-05-31 | GSE75571 | GEO

Gene expression in mouse liver in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in six strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age Tissues were collected from mice at 22 weeks of age; there were 96 microarrays used in total: for each of the 6 strains of mice, there were 8 control-fed mice and 8 calorie restricted mice (one individual mouse per microarray)

2013-09-26 | E-GEOD-50789 | biostudies-arrayexpress

Gene expression in mouse epididymal white adipose tissue in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in epididymal white adipose tissue (WAT) in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

2017-05-31 | GSE75573 | GEO

Effects of 20 months Dietary Methionine Restriction on Hepatic Gene Expression in Fischer 344 Rats

Project description:Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the liver. We analyzed MR-induced changes in gene expression using pooled RNA from liver of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.

2012-04-07 | E-GEOD-28482 | biostudies-arrayexpress

Short-Term Modified Atkins Diet Induced Molecular Changes in Epilepsy Brain and Plasma

Project description:Background There is evidence that shifting brain metabolism with high fat and low carbohydrate diets can reduce seizure frequency in some treatment-resistant epilepsy patients, including the more flexible Modified Atkins Diet (MAD) that is more palatable, mimicking fasting and high ketone body levels. Low carbohydrate diets shift brain energy production from glycolysis to fatty acid beta-oxidation, particularly impacting neuron and astrocyte related metabolism. Methods and findings We evaluated the effect of short-term MAD on molecular mechanisms in surgical brain tissue from adult treatment-resistant epilepsy patients and plasma compared to Control participants consuming a non-modified higher carbohydrate diet (failure of > 2 anti-seizure medications; n = 6 MAD, mean age 43.7 years, range 21-53, diet average 10 days; n = 10 Control, mean age 41.9 years, range 28-64). There were 13 altered metabolites in plasma, including increased ketone body 3-hydroxybutyric acid, 1 metabolite in cortex, and 11 metabolites in hippocampus that were associated with mitochondrial function. Cortex and plasma 3-hydroxybutyric acid levels correlated (p = 0.0088, R2 = 0.48). Brain proteomics and RNAseq identified few differences, with trends seen in hippocampal NADH related signaling pathways (activated oxidative phosphorylation and inhibited sirtuin signaling). Conclusions Short-term MAD resulted in early metabolic changes in plasma and resected epilepsy brain tissue, in combination with trending changes seen in hippocampal NADH related signaling pathways. Future studies should evaluate how brain molecular mechanisms are altered with long-term MAD, with correlations to seizure frequency, epilepsy syndrome, and other clinical variables. [Clinicaltrials.gov NCT02565966]

2022-07-11 | MSV000089863 | MassIVE

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