Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential gene expression in paired SMC vs. Non-SMC

ABSTRACT: Differential gene expression in paired SMC vs. Non-SMC

PROVIDER: PRJNA664763 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

ATAC-seq in paired SMC vs. Non-SMC

Project description:ATAC-seq in paired SMC vs. Non-SMC

| PRJNA664053 | ENA

Differential gene expression in paired SMC vs. Non-SMC

Project description:Poor prognosis of small cell lung cancer (SCLC) is mainly attributed to its highly metastatic capability. Here we identify the SMC and Non-SMC from Rb1L/L/Trp53 L/L mouse model through FACS with NE and mensenchymal markers. In order to identify functions of these two subpopulations during SCLC malignant progression, we compared their metastatic capability by allograft experiment. In addition, we find that the SMC is progressively transited from the Non-SCLC during mouse SCLC malignant progression. Further investigation reveals that genetic disruption of the SWI/SNF chromatin-remodeling complex, in RP model abrogates SMC phenotype maintenance and SCLC metastasis. In search of important downstream regulators, we find that TAZ, the core transcription cofactor of the Hippo pathway, is epigenetically silenced by SWI/SNF complex during this process. Collectively, our data link phenotypic transition to cancer metastasis and identify TAZ as a critical molecular switch that controls SCLC plasticity.

2022-08-24 | GSE158293 | GEO

ATAC-seq in paired SMC vs. Non-SMC

2022-08-24 | GSE158091 | GEO

Differential gene expression in SMC Ctrl vs TAZ4SA

Project description:Differential gene expression in SMC Ctrl vs TAZ4SA

| PRJNA664759 | ENA

Differential gene expression in paired H146-iPAX5 vs. H146

Project description:Differential gene expression in paired H146-iPAX5 vs. H146

| PRJNA1181807 | ENA

Differential gene expression in SMC Ctrl vs TAZ4SA

2022-08-24 | GSE158290 | GEO

Ethanol treated vs paired control

Project description:Ethanol treated vs paired control

| PRJNA92253 | ENA

The non-canonical SMC protein SmcHD1 antagonises TAD formation on the inactive X chromosome (Repli-seq)

Project description:In this study we investigate the role of the non-canonical SMC family protein, SmcHD1in the X inactivation.

2018-11-07 | GSE122196 | GEO

Pancreatic cancer vs. paired normal control

Project description:The miRNA expression between normal and cancerous pancreatic tissues and identified preferentially expressed miRNAs. Two-condition experiment, pancreatic cancer vs. paired normal control. Biological replicates: 3 paired patients tissues.

2011-04-26 | E-GEOD-28862 | biostudies-arrayexpress

Swarming sample vs non-swarming sample

Project description:Swarming sample vs non-swarming sample

| PRJNA634263 | ENA