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Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [ATAC-Seq]

ABSTRACT: Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [ATAC-Seq]

PROVIDER: PRJNA666788 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12755864_1.fastq.gz	Fastqsanger.gz
	SRR12755864_2.fastq.gz	Fastqsanger.gz
	SRR12755865_1.fastq.gz	Fastqsanger.gz
	SRR12755865_2.fastq.gz	Fastqsanger.gz
	SRR12755866_1.fastq.gz	Fastqsanger.gz

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Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration

Project description:Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration

| PRJNA666797 | ENA

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [scATAC-Seq]

Project description:Adult liver has enormous regenerative capacity as it can regenerate after losing two-thirds of its mass while sustaining essential metabolic functions. How the liver balances dual demands for increased proliferative activity with maintenance of organ function is unknown, but essential to prevent liver failure. Using partial hepatectomy (PHx) in mice to model liver regeneration, we integrated single-cell RNA and ATAC sequencing to map state transitions in ~ 13,000 hepatocytes at single-cell resolution as livers regenerated, and validated key findings with immunohistochemistry, to uncover how the organ regenerates hepatocytes while simultaneously fulfilling its vital tissue-specific functions. After PHx, hepatocytes rapidly and transiently diversified into multiple distinct populations with distinct functional bifurcation: some retained the chromatin landscapes and transcriptomes of hepatocytes in undamaged adult livers while others transitioned to acquire chromatin landscapes and transcriptomes of fetal hepatocytes. Injury-related signaling pathways known to be critical for regeneration were activated in transitioning hepatocytes and the most fetal-like hepatocytes exhibited chromatin landscapes that were enriched with transcription factors regulated by those pathways.

2020-10-02 | GSE158873 | GEO

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [scRNA-Seq]

2020-10-02 | GSE158866 | GEO

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [ATAC-Seq]

2020-10-02 | GSE158865 | GEO

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [RNA-Seq]

2020-10-02 | GSE158864 | GEO

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [RNA-Seq]

Project description:Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [RNA-Seq]

| PRJNA666787 | ENA

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [scRNA-Seq]

Project description:Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [scRNA-Seq]

| PRJNA666791 | ENA

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [scATAC-Seq]

Project description:Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration [scATAC-Seq]

| PRJNA666800 | ENA

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-02 | GSE158874 | GEO

Wnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes

Project description:The liver has a remarkable capacity to regenerate, which is sustained by the ability of hepatocytes to act as facultative stem cells that, while normally quiescent, re-enter the cell cycle upon injury. In rodents, growth factor signaling is indispensable, whereas Wnt/β-catenin is not required for effective tissue repair. However, molecular networks controlling human liver regeneration remain unclear.

2024-05-22 | PXD036100 | Pride

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