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The effect of BMP4 and BMP6 stimulation on adult muscle stem cells (MuSC)

ABSTRACT: The effect of BMP4 and BMP6 stimulation on adult muscle stem cells (MuSC)

PROVIDER: PRJNA669835 | ENA |

REPOSITORIES: ENA

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The effect of BMP4 and BMP6 stimulation on adult muscle stem cells (MuSC)

Project description:Muscle development and regeneration strongly depends on extracellular cues and growth factors, which are taken up by muscle stem cells and guide them either towards proliferation and fusion or towards quiescence. Here we investigated the effect of bone morphogenetic protein (BMP) signaling on Pax7 positive adult muscle stem cells of the mouse. We discovered a cross talk between the BMP- and NOTCH-signalling pathways, leading to high upregulation upon BMP4/BMP6-stimulation of Hes1 mRNA which is a key component of the NOTCH-siganling pathway.

2023-10-01 | GSE159594 | GEO

The effect of BMP4/6 stimulation on adult muscle stem cells (MuSC)

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The effect of BMP4/6 stimulation on adult muscle stem cells (MuSC)

Project description:The effect of BMP4/6 stimulation on adult muscle stem cells (MuSC)

| PRJNA525422 | ENA

8 hours BMP6 treated vs untreated human mesenchymal stem cells (hMSC)

Project description:We have established that BMP6 is an important endogenous regulator of human osteoblast differentiation. Our preliminary experiment showed that 8 hour BMP6 treatment induced early osteoblast markers in hMSC. In this study, we used microarrays to profile the global gene expression program in hMSC induced by BMP6 treatment and further identify the early osteogenic responses to BMP6 stimulation. Keywords: Stress response

2009-06-01 | GSE13604 | GEO

Transcription profiling of human mesenchymal stem cells treated for 8 hours with BMP6

2009-06-08 | E-GEOD-13604 | biostudies-arrayexpress

Short-term Activin A and BMP4 stimulation experiments with human ES cells

Project description:This experiment was carried out to identify the short-term effects of Activin A and BMP4 stimulation on gene expression in human embryonic stem cells grown in a chemically defined medium. Keywords: Growth factor stimulation experiment

2008-03-12 | GSE9060 | GEO

Transcriptomic analysis of BMP4/GREM1 stimulation on primary myoblasts

Project description:Transcriptomic analysis of BMP4/GREM1 stimulation on primary myoblasts

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Apelin Stimulation of the Perivascular MuSC Niche Enhances Endogenous Repair in Muscular Dystrophy

Project description:Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here we describe that defects in the endothelial cell (EC) compartment of the perivascular stem cell niche in three different types of MD are associated with inefficient mobilization of MuSCs following tissue damage. Using chemoinformatic analysis, we identified the 13 amino acid form of the peptidic hormone apelin (AP-13) as a candidate for systemic stimulation of skeletal muscle ECs. In dystrophic mice, administration of AP-13 generates a pro-myogenic EC-rich niche that supports MuSC function and markedly improves tissue regeneration, muscle strength, and physical performance. Moreover, we demonstrate that EC specific knockout of the AP-13 receptor leads to regenerative defects that phenocopy major pathological features of MD. Altogether, we provide in vivo proof-of-concept that enhancing endogenous repair by targeting the perivascular niche is a viable therapeutic avenue for MD and characterize AP-13 as a novel drug candidate for systemic treatment of stem cell dysfunction.

2024-03-20 | GSE240983 | GEO

Stimulation of human umbilical venous endothelial cells (HUVECs) with bone morphogenetic protein 4 (BMP4).

Project description:Backround: Several microRNAs have been characterized to regulate the process of angiogenesis. Previously, bone morphogenetic protein 4 (BMP4) was shown to increase the proangiogenic activity of endothelial cells. Aim: In this project we investigated how the proangiogenic BMP4 effect is mediated by microRNAs. Experimental design: To investigate changes in the microRNA transcriptome in HUVECs a time course experiment (12, 18 and 24 h) was performed. HUVECs were kept in endothelial basal medium either with BMP4 (25 ng/ml) stimulation or buffer control (4 mM HCL with 0.1% bovine serum albumin). Comparison between stimulated vs. unstimulated cells at different time points. followed by a miRNA microarray analysis was performed.

2017-02-01 | E-MTAB-4383 | biostudies-arrayexpress

Tubastatin A maintains skeletal muscle stem cell (MuSC) quiescence

Project description:We show that Tubastatin A (TubA) preserves MuSC quiescence and stem cell potency ex vivo, by inhibiting HDAC6 and, consequently, primary cilium resorption. Treatment with TubA improves MuSC engraftment potential and induces a return to quiescence in cycling MuSCs, revealing a potentially valuable approach to enhancing the therapeutic potential of MuSCs. To examine the state of quiescence preserved by TubA at the transcriptome level, we performed RNA-Seq and we found that TubA-treated MuSCs exhibit a quiescent transcriptome. The molecular mechanisms involved in the maintenance of quiescence by TubA were ribosome- and oxidative phosphorylation-related genes as well as low expression levels of cell cycle genes and Hh signaling genes.

2022-01-28 | GSE178070 | GEO

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