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RNMT regulates the activated CD4 T cell transcriptome and translatome [Ribo-Seq]

ABSTRACT: RNMT regulates the activated CD4 T cell transcriptome and translatome [Ribo-Seq]

PROVIDER: PRJNA672952 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12925946_1.fastq.gz	Fastqsanger.gz
	SRR12925946_2.fastq.gz	Fastqsanger.gz
	SRR12925947_1.fastq.gz	Fastqsanger.gz
	SRR12925947_2.fastq.gz	Fastqsanger.gz
	SRR12925948_1.fastq.gz	Fastqsanger.gz

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RNMT regulates the activated CD4 T cell transcriptome and translatome [Ribo-Seq]

Project description:We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs which are targets of the m7G-cap binding protein LARP1. These ribosome footprinting experiments investigate the effect of Rnmt cKO on the activated CD4 T cell transcriptome and translatome.

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Rnmt cKO vs control activated CD4 T cell ribo Mega-SEC

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RNMT regulates the CD4 T cell transcriptome and translatome

Project description:RNMT regulates the CD4 T cell transcriptome and translatome

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Rnmt cKO versus control activated CD4 T cells

Project description:We aim to find the gene-specific effects of Rnmt KO in mouse CD4 T cells. TMT proteomics datasets were generated to find out which proteins are dependent on RNMT for their expression.

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Rnmt and Ram regulate the activated CD4 T cell transcriptome

Project description:We investigated the role of RNMT and its cofactor RAM in T cells using conditional knockout mouse models. We demonstrate that RNMT and RAM have broadly overlapping roles in CD4 T cell activation.

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Project description:We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs which are targets of the m7G-cap binding protein LARP1. These RNAseq experiments investigate the effect of Rnmt cKO on the naïve CD4 T cell transcriptome.

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Ribo-tag translatome analysis from Split-Cre transgenic mice

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Project description:We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs and small RNAs including snoRNAs. To deterine if had any effect on ribosomal RNA modification we carried out pseudoridine sequencing.

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