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ABSTRACT: Rousettus aegyptiacus (Egyptian fruit bat) Genome sequencing, assembly and annotation

PROVIDER: PRJNA674394 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	JACASE01.dat.gz	Other
	JACASE01.fasta.gz	Fasta.gz
	JACASE01.master.dat	Other
	SRR11773222_1.fastq.gz	Fastqsanger.gz

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Rousettus aegyptiacus isolate:mRouAeg1

Project description:Rousettus aegyptiacus (Egyptian fruit bat) Genome sequencing, assembly and annotation

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Different Egyptian rousette interferon omega proteins elicit an overlapping but not identical transcriptional response in bat cells.

Project description:Abstract from accompanying publication: "Bats host a number of viruses that cause severe disease in humans without experiencing overt symptoms of disease themselves. While the mechanisms underlying this ability to avoid sickness are not known, deep sequencing studies of bat genomes have uncovered genetic adaptations that may have functional importance in the antiviral response of these animals. Egyptian rousette bats (Rousettus aegyptiacus) are the natural reservoir hosts of Marburg virus (MARV). In contrast to humans, these bats do not become sick when infected with MARV. A striking difference to the human genome is that Egyptian rousettes have an expanded repertoire of IFNW genes. To probe the biological implications of this expansion, we synthesized IFN-ω4 and IFN-ω9 proteins and tested their antiviral activity in Egyptian rousette cells. Both IFN-ω4 and IFN-ω9 showed antiviral activity against RNA viruses, including MARV, with IFN-ω9 being more efficient than IFN-ω4. Using RNA-Seq, we examined the transcriptional response induced by each protein. Although the sets of genes induced by the two IFNs were largely overlapping, IFN-ω9 induced a more rapid and intense response than did IFN-ω4. About 13% of genes induced by IFN-ω treatment are not found in the Interferome or other ISG databases, indicating that they may be uniquely IFN-responsive in this bat."

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Infection of RoNi cells with Sendai Cantell virus, MARV371bat virus, and VP35 mutant MARV371bat-R301A virus at MOI of 1.0

Project description:Study was performed in order to determine the scope of antiviral response of Rousettus aegyptiacus-derived fibroblasts to Sendai and Marburg virus infection. This study aids in understanding the function of the expanded immune repertoire of Rosettus aegyptiacus.

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Infection of RoNi cells with Sendai Cantell virus at MOI of 1.0

Project description:Study was performed in order to determine the type and scope of interferon response of Rousettus aegyptiacus-derived fibroblasts to Sendai virus infection. This study helps to understand the function of the expanded immune repertoire of Rosettus aegyptiacus.

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Project description:Dermal fibroblasts from bat and human, stimulated with dsRNA (poly(I:C)) and controls. Bats can harbor some of the most deadliest viruses to humans while rarely displaying pathogenicity themselves. To study the transcriptional divergence and cell-to-cell variability of their innate immune response - the expression program that is initiated once a pathogen is sensed, we stimulated dermal fibroblast cells from Rousettus aegyptiacus and from human for four hours with dsRNA - a viral RNA mimic that triggers a rapid innate immune response. Subsequently, we profiled the response using scRNA-seq.

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