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Transcriptome analysis upon Hmg20a knockdown in astrocytes

ABSTRACT: Transcriptome analysis upon Hmg20a knockdown in astrocytes

PROVIDER: PRJNA677916 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13041462_1.fastq.gz	Fastqsanger.gz
	SRR13041462_2.fastq.gz	Fastqsanger.gz
	SRR13041463_1.fastq.gz	Fastqsanger.gz
	SRR13041463_2.fastq.gz	Fastqsanger.gz
	SRR13041464_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis upon Hmg20a knockdown in astrocytes

Project description:We recently demonstrated that the ‘Metabesity’ factor HMG20A is essential for beta cell functional maturity and adaptation to physiological stress. As this chromatin remodeling factor also dictates CNS development, we sought to determine whether HMG20A is expressed in astrocytes and whether it potentiates astrocyte function in response to environmental cues. To investigate the function and regulatory mechanism of HMG20A, RNA-seq was performed on astrocytes treated or not with a siHMG20A. HMG20A silencing in astrocytes resulted in repression of pro-inflammatory, cholesterol homeostasis and epithelial-to-mesenchymal transition pathways. This results indicate that HMG20A coordinates the astrocyte polarization state. Under physiological pressure such as obesity and insulin resistance that induces low grade inflammation, HMG20A expression is increased to induce astrogliosis in an attempt to preserve the neuronal network and glucose homeostasis. onetheless, a chronic metabesity state or functional mutations will result in lower levels of HMG20A, failure to promote astrogliosis and increase susceptibility of neurons to stress-mediated apoptosis.

2021-06-09 | GSE161334 | GEO

Transcriptome analysis upon PHF14 and HMG20A knockdown in MDA-MB-231 cells

Project description:Transcriptome analysis upon PHF14 and HMG20A knockdown in MDA-MB-231 cells

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Transcriptome analysis upon PHF14 and HMG20A knockdown in MDA-MB-231 cells

Project description:High mobility group proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. We have shown that the high mobility group protein HMG20A copurifies with the histone reader PHF14. To understand the common functions of HMG20A and PHF14 proteins in regulating the transcriptome, we have performed RNA-Seq expression analysis following depletion of each protein in the triple-negative breast cancer cell line MDA-MB-231. Results indicate that genes regulated by PHF14 largely overlap with those regulated by HMG20A.

2022-09-05 | GSE193476 | GEO

Transcriptome changes upon Cas13-based knockdown

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Transcriptome analysis of U87 cells upon LINC00152 knockdown

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Transcriptome analysis of human astrocytes upon FGF1 stimulation

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Transcriptome analyses of trophoblast upon YTHDF3 knockdown

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Transcriptome analyses of trophoblast upon ALKBH5 knockdown

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