Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis of human astrocytes upon FGF1 stimulation


ABSTRACT: In a previous study performed in our laboratory, the level of FGF1 RNA was found to be increased in remyelinated multiple sclerosis lesions compared to control brain (unpublished observation). Astrocytes play a key role in multiple sclerosis lesion formation. To shed light on potential FGF1-mediated functions in multiple sclerosis, the impact of FGF1 on astrocytes was investigated.

ORGANISM(S): Homo sapiens

SUBMITTER: Anita Friese 

PROVIDER: E-MTAB-2485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS lesions remyelinates completely. Enhancing remyelination is, therefore, a major aim of future MS therapies. Here we took a novel approach to identify factors that may inhibit or support endogenous remyelination in MS. We dissected remyelinated, demyelinated active, and demyelinated inactive white matter MS lesions, and compared transcript levels of myelination and inflammation-related genes using q  ...[more]

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