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Expression of miRNAs in the kidneys of db/db mouse

ABSTRACT: Expression of miRNAs in the kidneys of db/db mouse

PROVIDER: PRJNA679779 | ENA |

REPOSITORIES: ENA

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Expression of miRNAs in the kidneys of db/db mouse

Project description:The microRNAs (miRNAs) that can influence diabetic kidney disease (DKD) have not been fully characterized. The aim of this study was to identify the miRNAs that affect DKD and could be used as specific biomarkers or therapeutic agents. First, kidneys from two DKD mouse models were screened for differences in miRNA expression from control mice. We found that miRNA-125b-5p and miRNA-181-5p were specifically differentially expressed in the kidneys of DKD mice. Next, we administered miRNA-181b-5p-mimic to DKD mice, which reduced the albuminuria and abnormal mesangial expansion. Pathway analysis revealed that overexpression of miRNA-181-5p significantly altered the expression of 51 genes in the kidneys of DKD mice. Furthermore, the serum level of miRNA-125b-5p was significantly higher and that of miRNA-181-5p was lower in patients with DKD than in patients with other kidney diseases. These results suggest that miRNA-125b-5p and miRNA-181b-5p may represent novel diagnostic biomarkers and that miRNA-181b-5p may represent a therapeutic target for DKD.

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Project description:This research was detected the differentially expressed circular RNAs in the heart tissues of WT mouse and db/db mouse. We have completed the circRNA Arraystar mouse V.2 analysis of the 3 wt mouse and 3 db/db mouse age 3 month. Whole heart tissue RNA samples were collected and then were digested with RNAse R. Total RNA from each sample was quantified using the NanoDrop ND-1000. The sample preparation and microarray hybridization were performed based on the Arraystar?s standard protocols.

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