Project description:The historical focus of male lower urinary tract dysfunction (LUTD) has been benign prostatic enlargement and other aging-related processes. Little attention has been directed towards the influence of early life events on urinary physiology in advancing age. Here, we identify the intrauterine environment as a modifier of adult voiding function and risk factor for male LUTD. To model environmental chemical exposures, we exposed pregnant mice to the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD, 1 µg/kg), coinciding with initiation of lower urinary tract development in male fetuses. Fetal TCDD exposure incites abnormal urodynamics in adult male mice, including increased urinary voiding frequency. TCDD also enhances adult prostate sensitivity to electrically evoked muscle contraction, suggesting increased autonomic tone. IUL TCDD exposure stably increases noradrenergic axon density beginning in the fetal period and persisting into adulthood. These changes are accompanied by increased abundance of a neurotrophin, Artemin (Artn), in the fetal prostate. This is the first evidence that intrauterine chemical exposures can reprogram prostate neuroanatomical development and drive prostatic smooth muscle hyperactivity in adulthood, which may create a susceptible phenotype for aging-related male lower urinary tract dysfunction.
2021-02-09 | GSE166395 | GEO
Project description:Multi-omics of male lower urinary tract dysfunction
Project description:This is a prevalence study evaluating lower urinary tract, prolapse, bowel, and sexual symptoms in women with a colorectal disorder who are planning to undergo surgery.
The purpose of this study is to identify the number of women who complain of lower urinary tract and bowel problems, including frequency, urgency, urinary incontinence, fecal incontinence, pain with intercourse, and other sexual problems prior to undergoing surgical management for a colorectal disorder.
| 2054601 | ecrin-mdr-crc
Project description:The impact of urethral catheters on the lower urinary tract microbiota and development of catheter-associated urinary tract infection
| PRJNA1063747 | ENA
Project description:Distinguishing features of the urinary bacterial microbiome in patients with neurogenic lower urinary tract dysfunction
Project description:Pseudomonas aeruginosa is one of the most frequent pathogen dominant in complicated urinary tract infections (UTI). To unravel the adaptation strategies of P. aeruginosa to the conditions in the urinary tract and to define the underlying regulatory network an artificial growth system mimicking the conditions in the urinary tract was established. Transcriptome analyses were used to investigate the physiological status of P. aeruginosa under this conditions.