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Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [PBMC]

ABSTRACT: Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [PBMC]

PROVIDER: PRJNA681190 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13156762_1.fastq.gz	Fastqsanger.gz
	SRR13156762_2.fastq.gz	Fastqsanger.gz
	SRR13156763_1.fastq.gz	Fastqsanger.gz
	SRR13156763_2.fastq.gz	Fastqsanger.gz
	SRR13156764_1.fastq.gz	Fastqsanger.gz

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Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [PBMC]

Project description:Pulmonary arterial hypertension (PAH) is a devastating disease characterized by arteriopathy in the small to medium-sized distal pulmonary arteries, often accompanied by infiltration of inflammatory cells. Aryl hydrocarbon receptor (AHR), a nuclear receptor/transcription factor, detoxifies xenobiotics and regulates the differentiation and function of various immune cells. However, the role of AHR in the pathogenesis of PAH is largely unknown. Here, we explore the role of AHR in the pathogenesis of PAH. AHR agonistic activity in serum was significantly higher in PAH patients than in healthy volunteer and was associated with poor prognosis of PAH. Sprague-Dawley (SD) rats treated with the potent endogenous AHR agonist, 6-formylindolo[3,2-b]carbazole in combination with hypoxia develop severe pulmonary hypertension (PH) with plexiform-like lesions, whereas SD rats treated with the potent vascular endothelial growth factor receptor 2 inhibitors did not. Ahr-knockout (Ahr-/-) rats generated using the CRISPR/Cas9 system did not develop PH in the SU5416/hypoxia model. A diet containing Qing-Dai, a Chinese herbal drug, in combination with hypoxia led to development of PH in Ahr+/+ rats, but not in Ahr-/- rats. RNA-seq analysis, ChIP-seq analysis, immunohistochemical analysis, and bone marrow transplantation experiments shows that activation of several inflammatory signaling pathways were upregulated in endothelial cells and peripheral blood mononuclear cells, which led to infiltration of CD4+ IL-21+ T cells and MRC1+ macrophages into vascular lesions in an AHR-dependent manner. Taken together, AHR plays crucial roles in the development and progression of PAH and the AHR signaling pathway represents a promising novel therapeutic target for PAH

2021-02-26 | GSE162244 | GEO

Transcription profiling of human peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension

Project description:Microarray analysis of peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension.

2007-09-21 | E-GEOD-703 | biostudies-arrayexpress

Blood pulmonary arterial hypertension

Project description:Microarray analysis of peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension. Keywords = mononuclear cells Keywords = gene microarray Keywords = pulmonary arterial hypertension Keywords = Herpesvirus Keywords = biomarker Keywords: other

2003-11-15 | GSE703 | GEO

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [ChIP-Seq]

Project description:Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [ChIP-Seq]

| PRJNA681182 | ENA

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [day56 RNA-Seq]

Project description:Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [day56 RNA-Seq]

| PRJNA681189 | ENA

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [ChIP-Seq]

2021-02-26 | GSE162237 | GEO

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [day56 RNA-Seq]

2021-02-26 | GSE162243 | GEO

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [day 4 RNA-Seq]

Project description:Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [day 4 RNA-Seq]

| PRJNA681185 | ENA

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension [day 4 RNA-Seq]

2021-02-26 | GSE162239 | GEO

The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries

Project description:This SuperSeries is composed of the following subset Series: GSE15857: The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Kidney GSE15858: The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Liver Refer to individual Series

2010-05-05 | E-GEOD-15859 | biostudies-arrayexpress

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