Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparison of the transcriptome analysis of Tom[Low] and Tom[High] AT2 subpopulations in mice

ABSTRACT: Comparison of the transcriptome analysis of Tom[Low] and Tom[High] AT2 subpopulations in mice

PROVIDER: PRJNA682339 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Comparison of the transcriptome analysis of Tom[Low] and Tom[High] AT2 subpopulations in mice

Project description:Transgenic mice in two control (SftpCreERT2/+; Tomatoflox/flox) and Experimental (SftpCreERT2/+; Fgfr2bflox/flox; Tomatoflox/flox) groups were treated with tamoxifen (1mg/ml) in drinking water. The lungs were harvested at different time points (d4,d7 and d14) following tamoxifen treatment. RNA was isolated from AT2 cells sorted by FACS. FACS analysis showed two different Alveolar epithelial type 2 cells population with low and high RFP levels. RFP low and high populations showed different fgfr2b signaling gene expression in experimental versus control groups. The aim of the gene array experiment is to compare RFP low and high populations transcriptome. Moreover, we aim to analyze FGf10/fgfr2b, AT1 and AT2 and Wnt signiture and obtain KEGG- Pathways targeted.

2021-12-01 | GSE162588 | GEO

Comparison of expression data from DLD-1 subpopulations

Project description:Comparison of expression data from DLD-1 subpopulations

| PRJNA429473 | ENA

Comparison of expression data from DLD-1 subpopulations III

Project description:Comparison of expression data from DLD-1 subpopulations III

| PRJNA429476 | ENA

Comparison of expression data from DLD-1 subpopulations II

Project description:Comparison of expression data from DLD-1 subpopulations II

| PRJNA429477 | ENA

Comparison of expression data from DLD-1 subpopulations I

Project description:Comparison of expression data from DLD-1 subpopulations I

| PRJNA429474 | ENA

Comparison of transcriptomic profiles between dysplastic stem cell subpopulations

Project description:Comparison of transcriptomic profiles between dysplastic stem cell subpopulations

| PRJNA834965 | ENA

Solanum lycopersicum strain:Micro-Tom | cultivar:Micro-Tom

Project description:Solanum lycopersicum strain:Micro-Tom | cultivar:Micro-Tom Raw sequence reads

| PRJNA892011 | ENA

Gene expression profile at single cell level of total alveolar type II (AT2) cells and CD44hi AT2 cells

Project description:AT2 cells are the resident progenitor cells in alveoli, capable of self-proliferation and differentiation into alveolar type I cells during homeostatic maintenance and tissue regeneration. The AT2 cell population is heterogenous. We identified a small subpopulation of AT2 cells that express high levels of CD44 (CD44hi) and display progenitor functions during alveoli homeostasis. To further analyze the heterogeneity of the AT2 cell population and characterize CD44hi AT2 cells, we performed single cell RNA-seq on the total AT2 cell population and CD44hi AT2 cells.

2024-05-24 | GSE202226 | GEO

Etv5 ChIP-seq in AT2 cells

Project description:Alveolar type II (AT2) cell dysfunction contributes to a number of significant human pathologies including respiratory distress syndrome, lung adenocarcinoma, and debilitating fibrotic diseases, but the critical transcription factors that maintain AT2 cell identity are unknown. Here we show that the E26 transformation-specific (ETS) family transcription factor Etv5 is essential tomaintain AT2 cell identity. Deletion of Etv5 from AT2 cells produced gene and protein signatures characteristic of differentiated alveolar type I (AT1) cells. Consistent with a defect in the AT2 stem cell population, Etv5 deficiency markedly reduced recovery following bleomycin-induced lung injury. Lung tumorigenesis driven by mutant KrasG12D was also compromised by Etv5 deficiency. ERK activation downstream of Ras was found to stabilize Etv5 through inactivation of the cullin- RING ubiquitin ligase CRL4COP1/DET1 that targets Etv5 for proteasomal degradation. These findings identify Etv5 as a critical output of Ras signaling in AT2 cells, contributing to both lung homeostasis and tumor initiation.

2018-03-08 | GSE111569 | GEO

Gene expression variation in lymphocyte subpopulations in response to low dose of ionizing radiations

Project description:Lymphocytes are the standard cell of a majority of biodosimetry approaches because of their availability and radiosensitivity. But progresses remain to be performed to bring down the minimum threshold of dose sensitivity. To find a lymphocyte subtype able to respond to low doses of ionizing radiation, we examined gene expression variations in different lymphocyte subpopulations using the microarray technology. Blood samples were independently exposed to 0, 0.05 and 0.5 Gray of ionizing radiations. Three and 24 hours after exposure, CD56+, CD4+ and CD8+ cells were negatively isolated. RNA from each condition was competitively hybridized on oligonucleotide microarrays. Keywords: Dose response, stress response, cell type comparison

2008-02-01 | GSE6978 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data