Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Transcriptome sequencing of wild-type and Lrig-null MEFs

PROVIDER: PRJNA684140 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13238545.fastq.gz	Fastqsanger.gz
	SRR13238546.fastq.gz	Fastqsanger.gz
	SRR13238547.fastq.gz	Fastqsanger.gz
	SRR13238548.fastq.gz	Fastqsanger.gz
	SRR13238549.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Expression Data from wild type and E2F4 null MEFs

Project description:We have used primary MEFs derived from wild type and E2F4 null mice growing asynchrounously in serum to generate a signature for E2F4 pathway activation. 10 wild type and 10 E2F4 null samples were each assayed using the Affymetrics Mouse Genome 430A 2.0 array. Keywords: Primary MEFs from wild type and E2F4 null mice

2008-07-11 | GSE11039 | GEO

G0S2 functions as a tumor supressor through represssion of Myc signaling pathways

Project description:Comparions on gene expression in murine embyonic fibroblasts (MEFs) wild-type vs G0S2 null MEFs

2016-06-01 | GSE74696 | GEO

Mus musculus

Project description:Expression Data from wild type and E2F4 null MEFs

| PRJNA107135 | ENA

Transcription profiling of mouse embyronic fibroblasts from wild type and E2F2 null mice to generate a signature for E2F2 pathway activation

Project description:We have used primary MEFs derived from wild type and E2F4 null mice growing asynchrounously in serum to generate a signature for E2F4 pathway activation. 10 wild type and 10 E2F4 null samples were each assayed using the Affymetrics Mouse Genome 430A 2.0 array. Experiment Overall Design: MEFs from 3 wild type embryos on a total of 10 cultutes were grown and harvested for RNA. MEFS from 5 E2F4 null embryos were grown on a total of 10 cultures.

2008-10-24 | E-GEOD-11039 | biostudies-arrayexpress

High resolution transcriptome-wide RNA cytosine methylome of Mouse Embryonic Fibroblasts

Project description:We report high resolution transcriptome-wide RNA cytosine methylome of Mouse Embryonic Fibroblasts (MEFs) revealed by an optimized new RNA bisulfite sequencing approach. Comparison of RNA methylation profile from wild-type and Dnmt2 -/- MEFs shows that only C38 in three tRNAs (tRNA-Asp, Gly and Val) is the target of Dnmt2 in MEFs at normal conditions.

2013-04-21 | GSE44359 | GEO

Expression profiling in primary embryonic fibroblasts deficient for the lats2 locus

Project description:We previously reported LATS2 null mice (Yabuta et al., 2007). LATS2 known as a tumor suppressor protein. However, the LATS2 mediated transcriptional regulation remains largely unknown. To investigate potential signaling pathways, we performed the expression profiling by using primary MEFs derived from wild type and LATS2 null mice.

2016-10-16 | GSE25536 | GEO

Expression changes in mouse embryo fibroblasts associated with the loss of menin (menin-null)

Project description:Multiple endocrine neoplasia, type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary and enteropancreatic endocrine tissues. Affected individuals carry a germline loss-of-function mutation of the MEN1 gene, and tumors arise after loss of the second allele. Homozygous loss of Men1 in the germline of mice results in early embryonic lethality, with defective development of neural tube, heart, liver, and craniofacial structures. We generated immortalized Wild type (Wt) and menin-null mouse embryo fibroblast (MEF) cell lines and evaluated their characteristics, including global expression patterns. The Wt and menin-null cell lines were aneuploid, and the nulls did not display tumorigenic characteristics in soft-agar assay. Expression arrays in menin-null MEFs revealed altered expression of several extracellular matrix proteins that are critical in organogenesis. Specifically, transcripts for fibulin-2 (Fbln2), periostin (Postn) and versican (Cspg2, chondroitin sulfate proteoglycan), genes critical for the developing heart and known to be induced by TGF-beta, were decreased in their expression in menin-null MEFs. Fbln2 expression was the most affected, and the reduction in menin-null MEFs for Fbln2, Postn and Cspg2 was 16.18, 5.37 and 2.15-fold respectively. Menin-null MEFs also showed poor response to TGF-beta-induced Smad3-mediated transcription in a reporter assay, supporting a role for menin in this pathway. The expression changes associated with the loss of the tumor suppressor menin provide insights into the defective organogenesis observed during early embryonic development in Men1-null mouse embryos. Keywords: Wild type and menin-null mouse embryo fibroblasts

2007-06-01 | GSE6513 | GEO

Identification of Oct4-dependent genes in vivo

Project description:Transcriptome analysis of Oct4 null and wild type preimplantation mouse embryos by RNA-sequencing

2013-06-06 | GSE47089 | GEO

Mus musculus

Project description:CREBBP (CBP) ChIP-seq in wild type and CBP null MEFs +/- dipyridyl

| PRJNA236594 | ENA

Gene expression profiling of E1A;HrasG12V mouse embryonic fibroblasts grown under physiological (5%) oxygen conditions, with wild-type p53 or p53 null

Project description:To investigate how pleiotropic the impact of p53 loss is on cellular function, generated isogenic, polyclonal wild-type (sgNTC) and p53-null (sgp53) E1A;HrasG12V mouse embryonic fibroblast cell lines using CRISPR/Cas9. Here we show gene expression analysis on p53 wild-type (sgNTC) and p53null (sgp53) E1A;HrasG12V MEFs grown under physiological oxygen conditions (5% oxygen).

2020-08-07 | GSE136355 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data