Project description:The functional contribution of many circular RNAs (circRNAs) to cancer is poorly understood. Here, we report that knockdown in sarcoma cells of the endogenous circRNA, circCsnk1g3, modulates changes in immune cell proportions and expression profiles in the tumor lung microenvironment.
Project description:We report transcriptomic changes in mouse soft-tissue sarcoma cells upon knock-down of the endogenous circRNA, circCsnk1g3. We find that circCsnk1g3 knockdown results in upregulation of signaling pathways related to both production of and response to type-I and type-II interferons
Project description:It has recently been demonstrated circular RNAs (circRNAs) involve in various biological processes, nevertheless, the function of circRNAs in medulloblastoma is still unknown. The present study aims to investigate the expression profiles of circRNAs in medulloblastoma and related mechanisms for tumorigenesis and progression of medulloblastoma.