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Transcriptome analysis of mercury chloride (HgCl2) treated H1299 human non-small cell lung carcinoma cells

ABSTRACT: Transcriptome analysis of mercury chloride (HgCl2) treated H1299 human non-small cell lung carcinoma cells

PROVIDER: PRJNA688255 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13313969_1.fastq.gz	Fastqsanger.gz
	SRR13313969_2.fastq.gz	Fastqsanger.gz
	SRR13313970_1.fastq.gz	Fastqsanger.gz
	SRR13313970_2.fastq.gz	Fastqsanger.gz
	SRR13313971_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of mercury chloride (HgCl2) treated H1299 human non-small cell lung carcinoma cells

Project description:Purpose: finding differential transcripts usage in environmentally harzardous chemical, mercury chloride (HgCl2) in human non-small cell lung carcinoma cells Methods: transcriptome analysis by the RNA-seq via mRNA pull-down Results: We found that HgCl2 increases cellular toxicity by the increasing of apoptosis via caspase-3 independent pathway in H12999 cells. Also, over thounds of altered gene expression pattern were detected from the RNA-seq analysis. Conclusions: mercury chloride (HgCl2) increases cytotoxic effects and apoptosis in H1299 cells through the caspase-3 independent pathway and changes the context of trascript

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Expression data from H1299 human non-small cell lung carcinoma cell lines stably expressing CHES1 compared with H1299 infected with an empty vector

Project description:The expression of the forkhead transcription factor CHES1, also known as FOXN3, is reduced in many types of cancers. In vitro, CHES1 expression suppresses cell proliferation in tumor cell lines but not in normal cells. Conversely shRNA-mediated depletion of CHES1 increases tumor cell proliferation. We used microarrays to characterize the gene expression changes induced by CHES1 in H1299 cancer cells H1299 cells were infected with a retroviral vector that expresses CHES1 or an empty vector. After 5 days of infection, RNA was extracted from three independent replicas of each condition. Total RNA was send to Genome Quebec service for hybridization with Affymetrix microarrays.

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