Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A single cell transcriptomic atlas identifies synapse-associated microglia in the developing zebrafish (single cells)

ABSTRACT: A single cell transcriptomic atlas identifies synapse-associated microglia in the developing zebrafish (single cells)

PROVIDER: PRJNA691919 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13429039.fastq.gz	Fastqsanger.gz
	SRR13429040.fastq.gz	Fastqsanger.gz
	SRR13429041.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

A single cell transcriptomic atlas identifies synapse-associated microglia in the developing zebrafish (bulk cells)

Project description:A single cell transcriptomic atlas identifies synapse-associated microglia in the developing zebrafish (bulk cells)

| PRJNA691918 | ENA

A single cell transcriptomic atlas identifies synapse-associated microglia in the developing zebrafish (single cells)

Project description:This study profiles developing and adult zebrafish macrophages and defines regional and functional microglial subtypes.

2021-08-23 | GSE164772 | GEO

Single cell sequencing of microglia in developing white matter

Project description:Microglia were FACS-isolated from developing mouse corpus callosum at postnatal days 0, 7, and 21, then sequenced by 10X Genomics single-cell sequencing.

2023-09-01 | GSE184476 | GEO

A single cell transcriptomic atlas identifies synapse-associated microglia in the developing zebrafish (bulk cells)

Project description:This study profiles developing and adult zebrafish macrophages and defines regional and functional microglial subtypes.

2021-08-23 | GSE164771 | GEO

Single cell sequencing of microglia in developing white matter

Project description:Single cell sequencing of microglia in developing white matter

| PRJNA764733 | ENA

Microglial remodeling of the extracellular matrix promotes synapse plasticity [Microglia]

Project description:This study defines a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus.

2020-07-01 | GSE150712 | GEO

Complement and microglia activation mediates stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex

Project description:Spatially heterogeneous synapse loss is a characteristic of many psychiatric and neurological disorders, but the underlying mechanisms are unclear. Here, we show that spatially-restricted complement activation mediates stress-induced heterogeneous microglia activation and synapse loss localized to the upper layers of the mouse medial prefrontal cortex (mPFC). Single cell RNA sequencing also reveals a stress-associated microglia state marked by high expression of the apolipoprotein E gene (Apoehigh) localized to the upper layers of the mPFC. Mice lacking complement component C3 are protected from stress-induced layer-specific synapse loss, and the Apoehigh microglia population is markedly reduced in the mPFC of these mice. Furthermore, C3 knockout mice are also resilient to stress-induced anhedonia and working memory behavioral deficits. Our findings suggest that region-specific complement and microglia activation can contribute to the disease-specific spatially restricted patterns of synapse loss and clinical symptoms found in many brain diseases.

2024-09-09 | GSE272813 | GEO

A single cell transcriptome atlas of the developing zebrafish hindbrain

Project description:A single cell transcriptome atlas of the developing zebrafish hindbrain

| PRJNA593433 | ENA

A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum

Project description:A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum

| PRJNA931291 | ENA

GABA-receptive microglia selectively sculpt developing inhibitory circuits

Project description:Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and therefore wiring precision. However, whether the remodeling of distinct synapses during development is mediated by specialized microglia is unknown. Here, using in vivo two-photon imaging, we show that GABA-receptive microglia selectively interact with inhibitory synapses during a critical window of mouse postnatal development. GABA initiates a transcriptional synapse remodeling program within these specialized microglia, which in turn sculpt inhibitory connectivity without impacting excitatory synapses. Ablation of GABAB receptors within microglia impairs this process and leads to stereotyped repetitive behavior and hyperactivity. These findings demonstrate that distinct microglia differentially engage with specific synapse types during development.

2021-11-09 | GSE159947 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data