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Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #2]

ABSTRACT: Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #2]

PROVIDER: PRJNA693832 | ENA |

REPOSITORIES: ENA

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Lipid signalling enforces functional specialization of Treg cells in tumours

Project description:Lipid signalling enforces functional specialization of Treg cells in tumours

| PRJNA693830 | ENA

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq]

Project description:Metabolic reprogramming enforces Treg cell functional specialization in tumors by coordinating fatty acid biosynthesis and inhibitory receptor signaling pathways. These findings point to new avenues to selectively targeting intratumoral Treg cells for cancer therapy.

2021-02-24 | GSE165258 | GEO

Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #2]

2021-02-24 | GSE165257 | GEO

Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #1]

2021-02-24 | GSE149573 | GEO

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq]

Project description:Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq]

| PRJNA693833 | ENA

Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #1]

Project description:Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #1]

| PRJNA629293 | ENA

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq EAE]

2021-02-24 | GSE166159 | GEO

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq EAE]

Project description:Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq EAE]

| PRJNA699485 | ENA

Lipid signalling enforces functional specialization of Treg cells in tumours

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-24 | GSE165259 | GEO

Cognate antigen recognition defines intestinal Treg specialization and stability

Project description:Regulatory CD4 T cells (Treg) confer non-overlapping functions in intestinal immune tolerance, tissue maintenance, repair, and regeneration. Cytokines and T cell receptor (TCR) signals, in combination with environmental cues, direct Treg proliferation and differentiation. However, how intestinal antigens shape intestinal Treg populations, their specialization and stability remain unknown. Here we show that only Treg bearing specific TCRs expand in the colon, resulting in highly oligoclonal Treg populations. Treg TCR repertoires are private, but crucially, when the same repertoire of polyclonal Treg was transferred into different recipients, the same clones expanded in each recipient, suggesting that cognate TCR-antigen interactions drive colonic Treg accumulation. Expanded Treg clones were correlated with Treg stability and individual transcriptional states that were maintained in different recipients irrespective of the presence or absence of intestinal inflammation. Our data suggest a role for antigen recognition in the selection and functional specialization of intestinal Treg. We speculate that the therapeutic use of Treg must take into account TCR context-mediated properties to optimise Treg stability and function in vivo.

2024-03-13 | GSE260965 | GEO

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