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Stable overexpression of IRF8 in hepatocellular carcinoma cells hepa1-6 xenograft derived tumors in C57bl/6 mice

ABSTRACT: Stable overexpression of IRF8 in hepatocellular carcinoma cells hepa1-6 xenograft derived tumors in C57bl/6 mice

PROVIDER: PRJNA700621 | ENA |

REPOSITORIES: ENA

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Stable overexpression of IRF8 in hepatocellular carcinoma cells hepa1-6 xenograft derived tumors in C57bl/6 mice

Project description:Interferon regulatory factor 8 (IRF8), also known as interferon consensus sequence-binding protein, is an essential lineage-specific transcriptional regulator in the IRF family, controls diverse cellular processes and is has been implicated in innate immunity, immune cell differentiation. IRF8 has been shown to have both oncogenic and tumor suppressor activities, in myeloid cells and nonhematopoietic cells. As a transcription factor, other functions which may contribute to its oncogenic and anti tumor potential are not clear. So it is meaningful to study the role of IRF8 in different diseases. The roles and the underlying mechanisms of intrahepatic IRF8 in Hepatocellular carcinoma have not been reported up to date.

2023-02-01 | GSE166368 | GEO

Stable overexpression of IRF8 in hepatocellular carcinoma cells

Project description:Stable overexpression of IRF8 in hepatocellular carcinoma cells

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Microarray analysis of LRRC3B stable cell derived xenograft tumors

Project description:To understand how LRRC3B exerted tumor supprissive function in tumorigenesis assay, we performed microarray analysis of LRRC3B stable cell derived xenograft tumors. Keywords: Xenograft tumor

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Next Generation Sequencing Facilitates Quantitative Analysis of Hepa1-6 cells treated with 50 μM TMAO and 50ng/ml TNF-α Transcriptomes

Project description:Liver cancer has a high mortality rate. Chronic inflammation is one of the leading causes of hepatocellular carcinoma. Recent studies suggested high levels of trimethylamine N-oxide (TMAO) may correlate with increased risk of inflammatory-induced liver cancer. However, the mechanisms by which TMAO promotes liver cancer remain elusive. Here, we established a model of inflammatory-induced liver cancer by treating Hepa1-6 cells with TNF-α. TMAO synergistically increased the proliferation, migration and invasion of Hepa1-6 cells in the presence of TNF-α. We conducted bulk RNA-Seq of the TMAO-treated cell model of inflammatory Hepatocellular carcinoma (HCC)

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Stable knockdown of PLAGL2 in hepatocellular carcinoma cells

Project description:Stable knockdown of PLAGL2 in hepatocellular carcinoma cells

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Next Generation Sequencing Facilitates Quantitative Analysis of LSEC and Hepa1-6 mono- and co-cultured

Project description:Purpose: investigating paracrine effects of mono- and/or co-cultured LSEC and Hepa1-6 Method: mRNA profiles of mono- and co-cultured LSEC and Hepa1-6 were generated by deep sequencing. Results: The RNA-seq data confirmed that extracellular matrix-encoding genes were up-regulated by co-cultured LSEC with Hepa1-6.

2023-01-31 | GSE202457 | GEO

miRNA Expression in 4 mouse Hepatocellular Carcinoma cells with different lymphatic metastasis potentials

Project description:The purpose of this study is to screen for microRNAs related to lymphatic metastasis in mouse Hepatocellular Carcinoma cells, named H22, Hepa1-6, Hca-P, and Hca-F. The lymphatic metastasis abilities of the cell lines are different.

2018-03-10 | GSE111614 | GEO

Gene expression profiles of Hepa1-6 tumors in C57Bl/6 mice

Project description:Chronological change of gene expression profile of Hepa1-6 tumors in C57Bl/6 Two-condition experiment

2012-07-02 | E-GEOD-38981 | biostudies-arrayexpress

Gene expression profiles of Hepa1-6 tumors in C57Bl/6 mice

Project description:Chronological change of gene expression profile of Hepa1-6 tumors in C57Bl/6

2012-07-03 | GSE38981 | GEO